Methods to Assess In Vivo Insulin Sensitivity and Insulin Secretion
Methods to Assess In Vivo Insulin Sensitivity and Insulin Secretion
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DOI：
10.1007/978-3-319-45015-5_11
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发表时间：
2018-01-01
期刊：
影响因子：
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通讯作者：
Trombetta, Maddalena
中科院分区：
文献类型：
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作者：
Bonadonna, Riccardo C.;Boselli, Linda;Trombetta, Maddalena
人类胰岛素敏感性/抵抗性和胰岛素分泌/β细胞功能的评估仍然是重大挑战。对这些特征的兴趣源于它们已被证明或推测的对许多病理状况的影响，例如肥胖、2 型糖尿病、动脉粥样硬化、非酒精性脂肪肝 (NAFLD)、阿尔茨海默病。已经开发了大量的测试和替代指数，并将其应用于许多实验和观察环境中，以测量这两个性状中每一个性状的精确值。本章回顾了胰岛素敏感性和 β 细胞功能评估的一般原则，并描述了最流行的测试及其优缺点。
The assessments of insulin sensitivity/resistance and of insulin secretion/beta cell function in humans are still significant challenges. The interest for these traits stems from their proved, or presumed, implications in a great number of pathological conditions, such as obesity, type 2 diabetes, atherosclerosis, nonalcoholic fatty liver disease (NAFLD), Alzheimer's disease. A wide number of tests and surrogate indexes have been developed and applied in many experimental and observational settings to gauge exact values for each of these two traits. In this chapter, the general principles underlying the assessments of insulin sensitivity and of beta cell function are reviewed, and the most popular tests are described with their pros and cons.