Cystatin C -: A marker of peripheral atherosclerotic disease?
Cystatin C -: A marker of peripheral atherosclerotic disease?
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DOI：
10.1016/j.atherosclerosis.2007.11.025
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发表时间：
2008-08-01
期刊：
影响因子：
5.3
通讯作者：
Svensson, P.
中科院分区：
文献类型：
--
作者：
Arpegard, J.;Oestergren, J.;Svensson, P.
胱抑素c除了作为肾小球滤过的标志物外，还可能是心血管疾病的独立标志物。然而，关于这一主题的研究很少，结果也不确定。我们的目的是进一步研究胱抑素C作为外周动脉粥样硬化疾病的独立标志物。方法：对103例外周动脉疾病（PAD）男性患者和96例年龄、性别相匹配的对照组进行血清胱抑素C、白细胞介素6 （IL6）、CRP和肌酐检测。根据Cockcroft公式计算肌酐清除率（CCr），根据MDRD公式计算估算肾小球滤过率（eGFR）。结果：pad患者胱抑素c浓度高于对照组（1.09 +/- 0.40 vs 0.95 +/- 0.17 mg/L） （p < 0.01）。CCr无差异：81 +/- 27 vs 82 +/- 22 mL/min， eGFR 76 +/- 21 vs 79 +/- 14 mL/min。两例患者胱抑素C与CCr log IL-6和log CRP相关(r = -0.60, p
It has been suggested that Cystatin C. besides its function as a marker of glomerular filtration, could be an independent marker of cardiovascular disease. However, studies on this topic are few and results have been indecisive. Our aim was to further investigate the subject of Cystatin C as an independent marker of peripheral atherosclerotic disease.Method: Blood samples were analysed for serum cystatin C, IL6, CRP and creatinine in 103 males with peripheral arterial disease (PAD) and 96 controls matched for age and sex. Creatinine clearance (CCr) was calculated according to Cockcroft's formula and estimated glomerular filtration rate (eGFR) was calculated according to MDRD formula.Results: Cystatin C-concentration was higher in PAD-patients compared to control 1.09 +/- 0.40 vs. 0.95 +/- 0.17 mg/L (p < 0.01). There was no difference in CCr: 81 +/- 27 vs. 82 +/- 22 mL/min or eGFR 76 +/- 21 vs. 79 +/- 14 mL/min. Cystatin C correlated to CCr log IL-6 and log CRP in both patients (r = -0.60, p