Prevalence of primary aldosteronism without hypertension in the general population: Results in Shika study
Prevalence of primary aldosteronism without hypertension in the general population: Results in Shika study
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DOI：
10.1080/10641963.2017.1339072
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发表时间：
2018-01-01
影响因子：
12.3
通讯作者：
Yoneda, Takashi
中科院分区：
文献类型：
--
作者：
Karashima, Shigehiro;Kometani, Mitsuhiro;Yoneda, Takashi
目的：最近的研究报道高血压患者中原发性醛固酮增多症（PA）的患病率较高。然而，关于普通人群中 PA 患病率的数据很少。因此，我们检查了一般人群（包括血压正常受试者）中 PA 的患病率。方法：测定了日本石川县志贺町堀松区和东松穗区 309 名年龄 > 40 岁受试者的血浆肾素活性 (ng/mL/hr)、血浆醛固酮浓度 (pg/mL) 和醛固酮肾素比率 (ARR)。结果：其中，195 名受试者（78 名男性，平均年龄：62 +/- 11 岁）未服用抗高血压药物：113 名血压正常受试者和 82 名高血压受试者。在这些条件下，68 名受试者（13 名男性，年龄 62 +/- 10 岁）的 ARR >200。在接受卡托普利抑制试验的 14 名受试者中，有 5 名受试者记录有 PA，总受试者的最低患病率为 2.6%（血压正常受试者为 1.8%，高血压受试者为 3.7%）。有趣的是，女性受试者在不同年龄的受试者之间表现出显着的 ARR 差异
Objective: Recent studies have reported a high prevalence of primary aldosteronism (PA) among hypertensive patients. However, few data exist regarding the prevalence of PA in the general population. Therefore, we examined the prevalence of PA in the general population including normotensive subjects. Methods: Plasma renin activity (ng/mL/hr), plasma aldosterone concentration (pg/mL) and aldosterone renin ratio (ARR) were determined in 309 subjects aged >40 years in Horimatsu and Higashi-Matsuho district, Shika-machi, Ishikawa, Japan. Results: Among them, 195 subjects (78 males, mean age: 62 +/- 11 years) did not take antihypertensive agents: 113 normotensive subjects and 82 hypertensive subjects. Under these conditions, 68 subjects (13 males, age 62 +/- 10 years) had an ARR >200. In 14 subjects who underwent captopril suppression test, PA was documented in 5 subjects, yielding a minimum prevalence of 2.6% in total subjects (1.8% in normotensive subjects and 3.7% in hypertensive subjects). Interestingly, females subjects demonstrated significant differences in ARR between subjects with age