Radiation-induced adaptive responses and bystander effects.
Radiation-induced adaptive responses and bystander effects.
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DOI：
10.2187/bss.18.247
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发表时间：
2004-12-01
期刊：
影响因子：
--
通讯作者：
Ohnishi, Takeo
中科院分区：
文献类型：
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作者：
Matsumoto, Hideki;Takahashi, Akihisa;Ohnishi, Takeo
辐射生物学的一个经典范例断言，对细胞、组织和生物体的所有辐射效应都是由于辐射的直接作用。然而，最近人们对辐射的间接作用越来越感兴趣，包括辐射诱导的适应性反应、旁观者效应、低剂量超敏反应和基因组不稳定性，这些都是对低剂量/低剂量率辐射的反应所表现出的特定应激模式。本文综述了辐射诱导的旁观者效应和适应性反应，对这两种现象进行了描述，并讨论了前者对后者的贡献。
A classical paradigm [correction of paradym] of radiation biology asserts that all radiation effects on cells, tissues and organisms are due to the direct action of radiation. However, there has been a recent growth of interest in the indirect actions of radiation including the radiation-induced adaptive response, the bystander effect, low-dose hypersensitivity, and genomic instability, which are specific modes of stress exhibited in response to low-dose/low-dose rate radiation. This review focuses on the radiation-induced bystander effect and the adaptive response, provides a description of the two phenomena, and discusses the contribution of the former to the latter.