Quantitative imaging of cochlear soft tissues in wild-type and hearing-impaired transgenic mice by spectral domain optical coherence tomography.
Quantitative imaging of cochlear soft tissues in wild-type and hearing-impaired transgenic mice by spectral domain optical coherence tomography.
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DOI：
10.1364/oe.19.015415
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发表时间：
2011-08-01
期刊：
影响因子：
3.8
通讯作者：
Oghalai JS
中科院分区：
文献类型：
--
作者：
Gao SS;Xia A;Yuan T;Raphael PD;Shelton RL;Applegate BE;Oghalai JS
人类听力损失常常是由于耳蜗内功能性软组织受损或畸形所致，但这些变化在当前的医学成像模式下无法察觉。我们试图确定光学相干断层扫描（OCT）是否能够利用小鼠模型评估与听力相关的软组织结构。我们对盖膜改变的以及处于正常发育过程中的离体耳蜗进行了成像。使用OCT可以看到软组织结构和预期的解剖学变化，定量测量证实了其检测与听力相关的关键变化的能力。
Human hearing loss often occurs as a result of damage or malformations to the functional soft tissues within the cochlea, but these changes are not appreciable with current medical imaging modalities. We sought to determine whether optical coherence tomography (OCT) could assess the soft tissue structures relevant to hearing using mouse models. We imaged excised cochleae with an altered tectorial membrane and during normal development. The soft tissue structures and expected anatomical variations were visible using OCT, and quantitative measurements confirmed the ability to detect critical changes relevant to hearing.