In vitro analysis of the response of multicellular tumor spheroids exposed to chemotherapeutic agents in vitro or in vivo.
In vitro analysis of the response of multicellular tumor spheroids exposed to chemotherapeutic agents in vitro or in vivo.
复制标题
体外或体内暴露于化疗药物的多细胞肿瘤球体反应的体外分析。
作者：
J. Yuhas;A. Tarleton;J. G. Harman
多细胞肿瘤球状体（MTS）已暴露于化疗药物在体外（氮芥）或在体内（环磷酰胺），并在体外分析的生长模式的改变。无论MTS是在体外还是在体内暴露，药物的主要作用是在正常MTS生长率恢复之前诱导剂量依赖性滞后期。腹膜腔中MTS暴露于静脉注射环磷酰胺导致的模式与体外暴露系统相似，但检测到宿主抗MTS反应。结合这两种方法，可以研究这些复杂肿瘤形式对化疗的反应。
Multicellular tumor spheroids (MTS) have been exposed to chemotherapeutic agents in vitro (nitrogen mustard) or in vivo (cyclophosphamide) and analyzed in vitro in terms of altered growth patterns. Whether the MTS were exposed in vitro or in vivo, the major effect of the drugs was to induce a dose-dependent lag period before the normal MTS growth rate resumed. Exposure of MTS in the peritoneal cavity to i.v. injection cyclophosphamide results in patterns similar to the in vitro exposure system, except that a host anti-MTS reaction was detected. In combination, these two methods allow the study of the responses of these complex tumor forms to chemotherapy.
催乳素在大鼠乳腺肿瘤 MTW9 生长中的作用。
影响因子：
6.4
作者：
Platica,M;Doody,J;Mandeli,JP;Hollander,VP
通讯作者：
Hollander,VP