Antiemetic efficacy of granisetron plus dexamethasone in bone marrow transplant patients receiving chemotherapy and total body irradiation
Antiemetic efficacy of granisetron plus dexamethasone in bone marrow transplant patients receiving chemotherapy and total body irradiation
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格拉司琼联合地塞米松对骨髓移植化疗及全身放疗患者的止吐效果
DOI：
10.1038/sj.bmt.1701565
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发表时间：
1999
影响因子：
4.8
通讯作者：
R. Champlin
中科院分区：
文献类型：
--
作者：
B. Abbott;C. Ippoliti;J. Bruton;J. Neumann;R. Whaley;R. Champlin
很少有关于格拉司琼在接受大剂量化疗和全身照射（TBI）的骨髓移植（BMT）受者中的止吐效果的试验。在这项单中心、开放标签、前瞻性的试验中，对26名接受含环磷酰胺方案（大多数患者连续2天每天接受60mg /kg）和TBI （12 Gy / 4天）的患者进行格拉司琼加地塞米松的止吐疗效和安全性评估。化疗或放疗前30分钟给予每日静脉注射剂量格拉司琼1mg加地塞米松10mg，并在最后一次调理治疗后持续24小时，中位数为6天（范围3-9天）。呕吐控制的定义是24小时内发生的呕吐次数，或对恶心或呕吐的抢救药物的需求。共有25名患者完成了186个可评估的治疗天。50%的患者完全缓解（按治疗天数计算的吐药控制），48%为主要缓解，2%为次要缓解，无失败。不良反应轻微，最常见的是腹泻（15%）、头痛（14%）和便秘（11%）。基于这些结果，格拉司琼加地塞米松的止吐方案在大剂量环磷酰胺和TBI的BMT调节中是有效和耐受性良好的。
Few trials exist regarding the antiemetic efficacy of granisetron in bone marrow transplant (BMT) recipients conditioned with high-dose chemotherapy and total body irradiation (TBI). In this single-center, open-label, prospective, trial, the antiemetic efficacy and safety of granisetron plus dexamethasone were evaluated in 26 patients conditioned with cyclophosphamide-containing regimens (the majority receiving 60 mg/kg per day on 2 consecutive days), and TBI (12 Gy divided over 4 days). Daily intravenous doses of granisetron 1 mg plus dexamethasone 10 mg were given 30 min prior to chemotherapy or radiation, and continued for 24 h after the last conditioning treatment for a median of 6 days (range 3–9). Emetic control was defined by the number of emetic episodes occurring within a 24 h period, or the requirement for rescue medication for nausea or vomiting. A total of 25 patients completed 186 evaluable treatment days. Response (emetic control by treatment days) was complete in 50% of patients, major in 48%, minor in 2%, and there were no failures. Adverse effects were minor, with diarrhea (15%), headache (14%), and constipation (11%) reported most often. Based on these results, the antiemetic regimen of granisetron plus dexamethasone appears effective and well tolerated during BMT conditioning with high-dose cyclophos- phamide and TBI.