Circulating visfatin in chronic obstructive pulmonary disease
Circulating visfatin in chronic obstructive pulmonary disease
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慢性阻塞性肺疾病中的循环内脂素
DOI：
10.1016/j.nut.2008.09.008
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发表时间：
2009-04-01
期刊：
影响因子：
4.4
通讯作者：
Luo, Fengming
中科院分区：
文献类型：
--
作者：
Liu, Xiaojing;Ji, Yulin;Luo, Fengming
目的：慢性阻塞性肺疾病（COPD）患者常发生营养不良和持续全身炎症反应。内脂素是一种新的脂肪因子，在某些炎症性疾病中表达增加。其血浆水平及其与COPD患者营养状况和炎症的关系尚不清楚。本研究比较了COPD患者和健康对照者血浆内脂素水平、营养状况和炎症标志物的变化。方法：检测35例COPD患者和28例健康对照者血浆内脂素、肿瘤坏死因子-α（TNF-α）和C反应蛋白（CRP）水平。身体成分进行了评估与生物电阻抗analysis.Results：显着降低体重指数和体脂百分比观察COPD患者与对照组相比。COPD组血浆内脂素水平高于健康对照组（2.07 ± 0.18 vs 1.88 ± 0.15 ng/mL，P < 0.001）。COPD患者的TNF-α和CRP水平也显著高于对照组。COPD组血浆CRP、TNF-α与内脂素呈正相关，两组内脂素与体重指数、体脂百分比均无显著相关性。这种增加的脂肪细胞因子与TNF-α和CRP显著相关。内脂素可能是一种新的促炎脂肪细胞因子。(C)2009年由Elsevier Inc.出版
Objective: Malnutrition and continuous systemic inflammation occur frequently in patients with chronic obstructive pulmonary disease (COPD). Visfatin is a new adipokine, which increases in some inflammatory diseases. Its plasma level and relation with nutritional status and inflammation in COPD remain unknown. This study compared visfatin levels, nutritional status, and inflammation markers in patients with COPD and healthy controls.Methods: Plasma visfatin, tumor necrosis factor-alpha (TNF-alpha) and C-reactive protein (CRP) were measured in 35 patients with COPD and 28 healthy controls. Body composition was assessed with bioelectrical impedance analysis.Results: Significantly lower body mass index and percentage of body fat were observed in patients with COPD compared with control subjects. The levels of plasma visfatin were higher in the COPD group compared with healthy controls (2.07 +/- 0.18 versus 1.88 +/- 0.15 ng/mL, P < 0.001). Levels of TNF-alpha and CRP were also significantly higher in patients with COPD compared with controls. Plasma CRP and TNF-alpha were positively correlated with visfatin in the COPD group, No significant correlations were found between visfatin and body mass index or percentage of body fat in both groups.Conclusion: Plasma visfatin levels increased in patients with COPD. This increased adipocytokine was significantly correlated with TNF-alpha and CRP. Visfatin may be a new proinflammatory adipocytokine in this disease. (C) 2009 Published by Elsevier Inc.