Whole-body magnetic resonance angiography with blood-pool agents
Whole-body magnetic resonance angiography with blood-pool agents
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DOI：
10.1007/s10406-007-0210-0
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发表时间：
2007-03-01
影响因子：
5.9
通讯作者：
Morana, Giovanni
中科院分区：
文献类型：
--
作者：
Kramer, Harald;Morana, Giovanni
虽然经常无症状，外周动脉疾病（PAD）与显着的发病率在很大比例的患者。在许多情况下，动脉粥样硬化是潜在的病理学，涉及整个动脉树。全身磁共振血管造影（MRA）可以快速、无创和准确地评估整个血管系统，并可用于诊断目的和监测糖尿病、马凡氏综合征和大动脉炎等疾病的血管受累。MRA已成功用于PAD高度狭窄、回腔静脉异常和颈动脉斑块成像的识别。颈动脉病变与严重的冠状动脉病变和肾动脉粥样硬化显著相关。一个血管床的症状性病变通常与其他血管区域的其他无症状动脉粥样硬化病变相关。MRA可能优于计算机断层扫描血管造影术，因为它可以使用几乎没有严重毒性的造影剂进行，并且不使用电离辐射。整个动脉血管的显示可以在< 90 s内实现，具有良好的灵敏度和特异性。最近的技术进步，例如并行成像和专用矩阵线圈的实现，已经进一步提高了图像质量，并且与血池造影剂，例如钆磷维司特三钠（Vasovist，Bayer Schering Pharma AG，柏林，德国）组合，可以实现延长的成像时间、更高的空间分辨率和更大的解剖覆盖范围。
Although often asymptomatic, peripheral arterial disease (PAD) is associated with significant morbidity in a large proportion of patients. Atherosclerosis is the underlying pathology in many instances, involving the whole arterial tree. Whole-body magnetic resonance angiography (MRA) permits rapid, non-invasive and accurate evaluation of the entire vascular system and can be used for both diagnostic purposes and monitoring of vascular involvement in diseases such as diabetes, Marfan's syndrome and Takayasu arteritis. MRA has been used successfully in the identification of high-grade stenosis in PAD, abnormalities of the ileocaval veins and carotid plaque imaging. Carotid disease is significantly correlated with severe coronary artery disease and renal artery atherosclerosis. Symptomatic lesions in one vascular bed are often related to additional asymptomatic atherosclerotic lesions in other vascular regions. MRA may be advantageous over computed tomographic angiography because it can be performed with contrast media virtually devoid of serious toxicity and without utilization of ionizing radiation. Display of the entire arterial vasculature can be achieved in < 90 s, with excellent sensitivity and specificity. Recent technological advances, such as parallel imaging and the implementation of dedicated matrix coils, have further increased image quality, and in combination with the blood-pool contrast agents, such as gadofosveset trisodium (Vasovist, Bayer Schering Pharma AG, Berlin, Germany), extended imaging time, higher spatial resolution and larger anatomical coverage can be achieved.