Frequency and mortality of sepsis and septic shock in China: a systematic review and meta-analysis.
Frequency and mortality of sepsis and septic shock in China: a systematic review and meta-analysis.
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中国脓毒症和脓毒性休克的发生频率和死亡率：系统评价和荟萃分析
DOI：
10.1186/s12879-022-07543-8
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发表时间：
2022-06-21
影响因子：
3.7
通讯作者：
Chai, Yan-Fen
中科院分区：
文献类型：
--
作者：
Liu, Yan-Cun;Yao, Ying;Yu, Mu-Ming;Gao, Yu-Lei;Qi, An-Long;Jiang, Tian-Yu;Chen, Zhen-Sen;Shou, Song-Tao;Chai, Yan-Fen
脓毒症是一种由感染引起的危及生命的器官功能障碍，是一个重大的公共卫生问题。本研究旨在评估中国院内败血症、严重败血症和感染性休克的发生率和病死率。应用计算机检索MEDLINE、Embase、PubMed、Cochrane图书馆1992年1月1日至2020年6月1日期间有关中国院内败血症、严重败血症和感染性休克的发生率和死亡率的研究。随机效应模型被用来估计脓毒症、严重脓毒症和感染性休克的合并频率和死亡率。我们的检索得到了846个结果，其中29个研究被纳入本综述。脓毒症的合并发生率为33.6%(95%CI为25.9%~41.3%，I2 = 为99.2%；p <； 为0.001)，合并死亡率为29.0%(95%CI为25.3%~32.8%，I2 = 为92.1%；p = 为0)，31.1%(95%CI为25.3%~36.9%，I2 = 为85.8%；p <； 0.001)和37.3%(95%可信区间28.6%~46.0%，I2 = 93.5%；p <； 0.001)。不同研究之间存在显著的异质性。由于纳入的研究为数不多，脓毒症的定义不断变化，脓毒症发生率和死亡率的趋势不足以进行分析。急诊科(ED)脓毒症的流行病学数据严重缺乏，迫切需要在这方面进行更多的研究。我们的研究结果表明，中国的脓毒症和感染性休克的发生率和死亡率远远高于北美和欧洲国家。根据我们的结果，在中国的大陆，败血症和感染性休克的发病率和死亡率极高，需要更多的医疗预算支持。目前严重缺乏有关ED中败血症和感染性休克的流行病学资料，迫切需要对其进行更多的研究。试验登记这项系统评价是根据系统评价首选报告项目说明(PROSPERO CRD42021243325)和荟萃分析方案(PRISMA-P)进行的。网上版载有补充材料，可在10.1186/s12879-022-07543-8查阅。
Sepsis, a life-threatening organ dysfunction induced by infection, is a major public health problem. This study aimed to evaluate the frequency and mortality of sepsis, severe sepsis, and septic shock in China. We Searched MEDLINE, Embase, PubMed, and Cochrane Library from 1 January 1992 to 1 June 2020 for studies that reported on the frequency and mortality of sepsis, severe sepsis, and septic shock conducted in China. Random effects models were performed to estimate the pooled frequency and mortality of sepsis, severe sepsis, and septic shock. Our search yielded 846 results, of which 29 studies were included in this review. The pooled frequency of sepsis was estimated at 33.6% (95% CI 25.9% to 41.3%, I2 = 99.2%; p < 0.001), and the pooled mortality of sepsis, severe sepsis and septic shock were 29.0% (95% CI 25.3%–32.8%, I2 = 92.1%; p = 0), 31.1% (95% CI 25.3% to 36.9%, I2 = 85.8%; p < 0.001) and 37.3% (95% CI 28.6%–46.0%, I2 = 93.5%; p < 0.001). There was significant heterogeneity between studies. With a small number of included studies and the changing definition of sepsis, trends in sepsis frequency and mortality were not sufficient for analysis. Epidemiological data on sepsis in the emergency department (ED) are severely lacking, and more research is urgently needed in this area is urgently needed. Our findings indicated that the frequency and mortality of sepsis and septic shock in China were much higher than North America and Europe countries. Based on our results, an extremely high incidence and mortality of sepsis and septic shock in China's mainland requires more healthcare budget support. Epidemiological data on sepsis and septic shock in ED are severely lacking, and more research is urgently needed in this area. Trial registration This systematic review was conducted according to the statement of the preferred reporting items for systematic review (PROSPERO CRD42021243325) and the meta-analysis protocols (PRISMA-P). The online version contains supplementary material available at 10.1186/s12879-022-07543-8.
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影响因子：
38.9
作者：
Weng, Li;Zeng, Xin-ying;Du, Bin
通讯作者：
Du, Bin
影响因子：
8.8
作者：
Martin, GS;Mannino, DM;Moss, M
通讯作者：
Moss, M
影响因子：
38.9
作者：
Xie J;Du B;Qiu H
通讯作者：
Qiu H
21世纪前十年中国大陆脓毒症流行病学及微生物学研究
影响因子：
8.4
作者：
Chen, Xin-Chuan;Yang, Yun-Fan;Chen, Xin-Zu
通讯作者：
Chen, Xin-Zu
DOI：
10.1155/2016/2565169
发表时间：
2016
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Li Y;Zhang X;Lin P;Qiu H;Wei J;Cao Y;Pan S;Walline J;Qian C;Shan Z;Yu X
通讯作者：
Yu X