Remote preconditioning- endocrine factors in organ protection against ischemic injury
Remote preconditioning- endocrine factors in organ protection against ischemic injury
复制标题
DOI：
10.2174/187153007781662585
复制
发表时间：
2007-09-01
影响因子：
1.9
通讯作者：
Schultz, Jo El J.
中科院分区：
文献类型：
--
作者：
Bolte, Craig S.;Liao, Siyun;Schultz, Jo El J.
心血管疾病是美国和发展中国家的主要死亡原因。实验和临床研究已经证明，包括短暂缺血或缺氧和某些内源性因子如阿片类药物、缓激肽、生长因子或药理学试剂的许多干预能够保护心脏免受缺血后收缩功能障碍、心律失常和心肌梗死。这种传统的心脏保护作用通过自分泌或旁分泌作用发生，其中这些保护因子从心脏释放并作用于自身。在过去的十年中，越来越多的证据表明，一个器官的缺血性损伤会释放内源性因子，保护其他器官免受长期缺血性损伤。这种现象，称为远程预处理或预处理的距离，暗示内分泌作用，并可能涉及体液或神经内分泌信号。本文将总结内分泌因素的确定和牵连，这种器官间的细胞保护。
Cardiovascular disease is the leading cause of death in the United States and developing world. Experimental and clinical studies have demonstrated that a number of interventions including brief periods of ischemia or hypoxia and certain endogenous factors such as opioids, bradykinin, growth factors or pharmacological agents are capable of protecting the heart against post-ischemic contractile dysfunction, arrhythmias and myocardial infarction. This conventional cardioprotection occurs via an autocrine or paracrine action in which these protective factors are released from the heart to act upon itself. Over the last ten years, a growing body of evidence indicates that a brier ischemic insult on one organ releases endogenous factors that protect other organs against a prolonged ischemic insult. This phenomenon, termed remote preconditioning or preconditioning at a distance, implicates an endocrine action, and may involve humoral or neural-endocrine signaling. This review will summarize the endocrine factors identified and implicated in this inter-organ cytoprotection.