The aryl hydrocarbon receptor and the gut-brain axis.

The aryl hydrocarbon receptor and the gut-brain axis.
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芳香烃受体和肠脑轴。

DOI:
10.1038/s41423-020-00585-5
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发表时间:
2021-03
影响因子:
24.1
通讯作者:
Quintana FJ
Quintana FJ
中科院分区:
医学1区
文献类型:
--
作者:
Barroso A;Mahler JV;Fonseca-Castro PH;Quintana FJ

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芳烃受体(AHR)是一种配体激活的转录因子,最初被认为是二恶英的受体。在AHR被发现近半个世纪后,它现在被认为是多种生理配体的受体,在健康和疾病中发挥着重要作用。在这篇综述中,我们讨论了AHR在肠脑轴中的作用及其作为免疫介导性疾病治疗靶点的潜在价值。
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially identified as the receptor for dioxin. Almost half a century after its discovery, AHR is now recognized as a receptor for multiple physiological ligands, with important roles in health and disease. In this review, we discuss the role of AHR in the gut–brain axis and its potential value as a therapeutic target for immune-mediated diseases.
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