Disappearance of diurnal rhythm of energy expenditure in genetically diabetic obese rats
Disappearance of diurnal rhythm of energy expenditure in genetically diabetic obese rats
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DOI：
10.2170/jjphysiol.48.211
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发表时间：
1998-06-01
期刊：
影响因子：
--
通讯作者：
Funakoshi, A
中科院分区：
文献类型：
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作者：
Ichikawa, M;Miyasaka, K;Funakoshi, A
在遗传性糖尿病肥胖大鼠的新动物模型中检查了每日能量消耗概况。在8周龄时观察到昼夜节律，每小时能量消耗的最高值和最低值分别在黑暗和光照期间观察到。然而，在非胰岛素依赖型糖尿病出现后的24周龄时，节律完全消失，但对照组大鼠没有。
The daily profile of energy expenditures was examined in the new animal model of genetically diabetic obese rats. The diurnal rhythm was observed at 8 weeks of age, with highest and lowest values for energy consumption per hour observed in the dark and light periods, respectively. However, at 24 weeks of age after the manifestation of noninsulin-dependent diabetes mellitus, the rhythm completely disappeared, but it did not in the control rats.