Temporal Lobe Volume Measurement from MR Images: Accuracy and Left‐Right Asymmetry in Normal Persons
Temporal Lobe Volume Measurement from MR Images: Accuracy and Left‐Right Asymmetry in Normal Persons
复制标题
磁共振图像颞叶体积测量：正常人的准确性和左右不对称性
DOI：
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发表时间：
1988
影响因子：
1.3
通讯作者：
A. Zinsmeister
中科院分区：
文献类型：
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作者：
C. Jack;D. Gehring;F. Sharbrough;J. Felmlee;G. Forbes;V. Hench;A. Zinsmeister
利用离线自动边界勾画和内部区域像素计数计算机程序，研究了几个磁共振变量对幻影物体体积测量精度的影响，并确定了一组最佳成像变量。从MR图像数据中测量了大体固定脑标本的颞叶体积。准确度范围为- 2 ~ + 7%，MR图像与阿基米德原理测量的左右叶体积差的标准差为1 cm3。这项体积测量技术应用于25名正常人，其中大多数是右撇子。左右颞叶容积比中位数为1.16（范围0.99 ~ 1.23）。非优势颞叶明显大于优势颞叶。左右容积的平均差值（95%置信区间）为7 cm3 （6-9 cm3）。该置信区间与考虑受试者内部的可变性（从总固定脑标本估计）时获得的置信区间相似。单侧颞叶萎缩，特别是颞叶癫痫患者，应该从MR图像中理解正常左右大小的差异范围。
The effect of several magnetic resonance (MR) variables on the accuracy of volume measurements in phantom objects was investigated by use of an off-line automatic border-outlining and internal area pixel-counting computer program, and an optimal set of imaging variables was identified. Measurements were made of the temporal lobe volumes of a gross fixed brain specimen from MR image data. The range in accuracy was from - 2 to + 7%, and the standard deviation of the difference in right minus left lobe volume measurements obtained from the MR images and those obtained by use of Archimedes' principle was 1 cm3. This volumetric technique was applied to 25 normal persons, most of whom were right-handed. The median ratio of right to left temporal lobe volume was 1.16 (range 0.99–1.23). The nondominant temporal lobe was significantly larger than the dominant. The mean difference (95% confidence interval) between right and left volumes was 7 cm3 (6–9 cm3). This confidence interval was similar to that obtained when the variability within a subject (estimated from the gross fixed brain specimen) was taken into account. Unilateral temporal lobe atrophy, particularly in patients with temporal lobe epilepsy, should be interpreted from MR images with this range of discrepancy in normal left-right size in mind.