Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivo.
Cardiac side population cells have a potential to migrate and differentiate into cardiomyocytes in vitro and in vivo.
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心脏侧种群细胞有可能在体外和体内迁移并分化为心肌细胞。
DOI：
10.1083/jcb.200603014
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发表时间：
2007-01-29
期刊：
影响因子：
--
通讯作者：
Komuro I
中科院分区：
文献类型：
--
作者：
Oyama T;Nagai T;Wada H;Naito AT;Matsuura K;Iwanaga K;Takahashi T;Goto M;Mikami Y;Yasuda N;Akazawa H;Uezumi A;Takeda S;Komuro I
侧群（SP）细胞，可以通过它们排除Hoechst 33342染料的能力来鉴定，是体干细胞的候选者之一。虽然骨髓SP细胞是已知的长期再生造血干细胞，有关于心脏SP细胞（CSP）的特性的信息很少。当用催产素或阿司他丁A处理新生大鼠心脏培养的CSP时，一些CSP表达心脏特异性基因和蛋白，并显示自发搏动。将绿色荧光蛋白阳性的CSPs静脉输注到成年大鼠体内，发现损伤心脏中CSPs迁移和归巢的数量是正常心脏的约12倍。受损心脏中的CSP分化为心肌细胞、内皮细胞或平滑肌细胞（分别占总CSP衍生细胞的4.4%、6.7%和29%）。这些结果表明，CSPs是内在的心脏干细胞，并参与病变心脏的再生。
Side population (SP) cells, which can be identified by their ability to exclude Hoechst 33342 dye, are one of the candidates for somatic stem cells. Although bone marrow SP cells are known to be long-term repopulating hematopoietic stem cells, there is little information about the characteristics of cardiac SP cells (CSPs). When cultured CSPs from neonatal rat hearts were treated with oxytocin or trichostatin A, some CSPs expressed cardiac-specific genes and proteins and showed spontaneous beating. When green fluorescent protein–positive CSPs were intravenously infused into adult rats, many more (∼12-fold) CSPs were migrated and homed in injured heart than in normal heart. CSPs in injured heart differentiated into cardiomyocytes, endothelial cells, or smooth muscle cells (4.4%, 6.7%, and 29% of total CSP-derived cells, respectively). These results suggest that CSPs are intrinsic cardiac stem cells and involved in the regeneration of diseased hearts.
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影响因子：
7.8
作者：
Asakura, Atsushi;Seale, Patrick;Girgis-Gabardo, Adele;Rudnicki, Michael A
通讯作者：
Rudnicki, Michael A
影响因子：
64.8
作者：
Laugwitz, KL;Moretti, A;Chien, KR
通讯作者：
Chien, KR
DOI：
10.1073/pnas.0407643101
发表时间：
2004-11-23
影响因子：
11.1
作者：
Hsieh, J;Nakashima, K;Gage, FH
通讯作者：
Gage, FH
影响因子：
13.6
作者：
Ito, T;Suzuki, A;Hori, M
通讯作者：
Hori, M
影响因子：
64.8
作者：
Gussoni, E;Soneoka, Y;Mulligan, RC
通讯作者：
Mulligan, RC