Cardiac structure and function in relation to central blood pressure components in Chinese
Cardiac structure and function in relation to central blood pressure components in Chinese
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DOI：
10.1097/hjh.0b013e32834c1e7d
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发表时间：
2011-10
影响因子：
4.9
通讯作者：
Yi Zhang;Yan Li;F. Ding;C. Sheng;Qi-Fang Huang;Ji-Guang Wang
中科院分区：
文献类型：
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作者：
Yi Zhang;Yan Li;F. Ding;C. Sheng;Qi-Fang Huang;Ji-Guang Wang
关于中心血压(BP)成分与心脏结构和功能的关联，背景数据有限。方法对某厂在职和离退休职工及其家属进行心血管健康检查。用SPhygmoCor测量中心血压，用超声心动图测量心脏结构和功能。结果调查对象826人，平均年龄43.0岁，其中女性285人(34.5%)，高血压患者184人(22.3%)，其中78人(42.4%)服用降压药。校正年龄、性别、体重、身高、降压治疗、吸烟和饮酒后，左房容量和左心室质量与臂部和中央部血压成分显著相关(r=0.09~0.21，P<0.001)，而以E/A比值和E波减速时间评价左室舒张功能不全仅与臂部和中央部收缩压显著相关(r=0.14~0.18，P&⩽；0.01)。然而，这些相关系数在臂动脉和中央动脉之间有数量上的差异，但没有显著差异(P≥0.06)。在调整相似的回归模型中，随着中心收缩压(16.7毫米汞柱)1-SD的增加，E/A比值显著降低5.5±1.2%，DTE显著增加4.66±1.22ms(P<；0.001)。分别对男性和女性以及排除服用降压药的患者后进行的敏感性分析是确认性的。结论心脏结构与中枢性血压成分显著相关，而左室舒张功能不全仅与中枢性SBP显著相关。
Background Data are limited with regard to the association of central blood pressure (BP) components with cardiac structure and function. Methods Our study was conducted in the framework of cardiovascular health examinations for the current and retired employees of a factory and their family members. We measured central BP by SphygmoCor and cardiac structure and function by echocardiography. Results The 826 participants (mean age 43.0 years) included 285 (34.5%) women and 184 (22.3%) hypertensive patients, of whom 78 (42.4%) took antihypertensive drugs. After adjustment for age, sex, body weight, body height, antihypertensive treatment, current smoking and alcohol intake, left atrial volume and left ventricular mass were significantly associated with brachial and central BP components (r = 0.09–0.21, P ⩽ 0.01), whereas left ventricular diastolic dysfunction, evaluated by E/A ratio and deceleration time of E wave (DTE), was only significantly associated with brachial and central SBP (r = 0.14–0.18, P < 0.001). However, these correlation coefficients were quantitatively but nonsignificantly different between brachial and central BP (P ≥ 0.06). In regression models with similar adjustments, with 1-SD increase in central SBP (16.7 mmHg), E/A ratio significantly decreased by 5.5 ± 1.2% and DTE significantly increased by 4.66 ± 1.22 ms (P < 0.001). Sensitivity analyses in men and women separately and after exclusion of patients on antihypertensive medication were confirmatory. Conclusion Cardiac structure was significantly and comparably associated with central BP components, but left ventricular diastolic dysfunction was only significantly associated with central SBP.