Amplitude reduction of the mismatch negativity in first-degree relatives of patients with schizophrenia
Amplitude reduction of the mismatch negativity in first-degree relatives of patients with schizophrenia
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DOI：
10.1016/s0304-3940(01)02072-9
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发表时间：
2001-08-31
影响因子：
2.5
通讯作者：
Heun, R
中科院分区：
文献类型：
--
作者：
Jessen, F;Fries, T;Heun, R
精神分裂症患者的一级亲属显示出与精神分裂症受试者相似的各种认知领域和电生理对应物的改变。失匹配负波（MMN）是一种反映听觉前注意阶段感觉记忆的事件相关电位。据报道，精神分裂症患者的MMN振幅降低。本研究调查了精神分裂症患者、一级亲属和对照组的MMN。与对照组相比，亲属的MMN振幅降低。然而，在本研究中，精神分裂症患者的MMN振幅降低与对照组相比并没有达到显著性。这些结果提供了精神分裂症患者亲属感觉记忆障碍的第一个证据。(C)2001爱思唯尔科学爱尔兰有限公司保留所有权利。
First-degree relatives of schizophrenic patients display alterations in various cognitive domains and their electrophysiological counterparts similar to schizophrenic subjects. The mismatch negativity (MMN) is an event-related potential that reflects sensory memory in the pre-attentive stage of auditory processing. An amplitude reduction of the MMN has been reported in schizophrenia. The present study investigated the MMN in patients with schizophrenia, first-degree relatives and control subjects. The MMN amplitude was reduced in relatives compared to controls. The MMN amplitude reduction in schizophrenic patients compared to controls, however, did not reach significance in the present study. These results provide first evidence for disturbed sensory memory in relatives of patients with schizophrenia. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.