TSPY, the candidate gonadoblastoma gene on the human Y chromosome, has a widely expressed homologue on the X -: implications for Y chromosome evolution
TSPY, the candidate gonadoblastoma gene on the human Y chromosome, has a widely expressed homologue on the X -: implications for Y chromosome evolution
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DOI：
10.1023/b:chro.0000034134.91243.1c
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发表时间：
2004-01-01
影响因子：
2.6
通讯作者：
Mitchell, MJ
中科院分区：
文献类型：
--
作者：
Delbridge, ML;Longepied, G;Mitchell, MJ
TSPY是促进性腺母细胞瘤形成因子（GBY）的候选基因，是人类Y染色体（MSY）男性特异性区域的睾丸特异性多拷贝基因家族。尽管最初提出Y染色体上的男性特异性基因起源于常染色体基因的转位拷贝（Lahn & Page 1999b），但至少有两个男性特异性基因（RBMY和SRY）来自先前重组的X-Y相同基因对。在人类（TSPX）和小鼠（TSPX）的X染色体上，一个具有相似基因结构的TSPY同源物位于靠近SMCX的保守位置。TSPX广泛表达，并受X失活的影响。因此，TSPX和TSPY是从原始哺乳动物性染色体上的同一基因对进化而来的。这支持了一种假设，即即使是Y染色体上的男性特异性基因也可能起源于x染色体上普遍表达的基因。由于独立的功能研究将TSPX与细胞周期调节联系起来，这也加强了TSPY作为GBY候选者的情况。
TSPY, a candidate gene for a factor that promotes gonadoblastoma formation (GBY), is a testis-specific multicopy gene family in the male-specific region of the human Y (MSY) chromosome. Although it was originally proposed that male-specific genes on the Y originated from a transposed copy of an autosomal gene (Lahn & Page 1999b), at least two male-specific genes (RBMY and SRY) descended from a formerly recombining X-Y identical gene pair. Here we show that a TSPY homologue with similar gene structure lies in conserved positions, close to SMCX, on the X chromosome in human (TSPX) and mouse (Tspx). TSPX is widely expressed and subject to X inactivation. TSPX and TSPY therefore evolved from an identical gene pair on the original mammalian sex chromosomes. This supports the hypothesis that even male-specific genes on the Y chromosome may have their origin in ubiquitously expressed genes on the X. It also strengthens the case for TSPY as a candidate for GBY, since independent functional studies link TSPX to cell cycle regulation.