Highlights of glucosamine-6P synthase catalysis
Highlights of glucosamine-6P synthase catalysis
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DOI：
10.1016/j.abb.2008.01.026
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发表时间：
2008-06-15
影响因子：
3.9
通讯作者：
Badet-Denisot, Marie-Anae
中科院分区：
文献类型：
--
作者：
Durand, Philippe;Golinelli-Pimpaneau, Beatrice;Badet-Denisot, Marie-Anae
L-谷氨酰胺：D-果糖-6-磷酸酰胺转移酶，也称为葡萄糖胺-6-磷酸合酶（GlcN6P合酶），催化形成尿苷5'-二磷酸-N-乙酰基-D-葡萄糖胺（UDP-GlcNAc）途径的第一步，是含氨基糖大分子生物合成代谢控制的关键点。 G1cN6P合酶催化反应的分子机制很复杂，涉及酰胺键断裂、氨通道和糖异构化。本文全面概述了有关这种多方面酶的现有知识，强调了过去五年中取得的进展。 (c) 2008 Elsevier Inc. 保留所有权利。
L-Glutamine:D-fructose-6-phosphate amidotransferase, also known as glucosamine-6-phosphate synthase (GlcN6P synthase), which catalyzes the first step in a pathway leading to the formation of uridine 5'-diphospho-N-acetyl-D-glucosamine (UDP-GlcNAc), is a key point in the metabolic control of the biosynthesis of amino sugar-containing macromolecules. The molecular mechanism of the reaction catalyzed by G1cN6P synthase is complex and involves amide bond cleavage followed by ammonia channeling and sugar isomerization. This article provides a comprehensive overview of the present knowledge on this multi-faceted enzyme emphasizing the progress made during the last five years. (c) 2008 Elsevier Inc. All rights reserved.