Specific effects of EEG based neurofeedback training on memory functions in post-stroke victims.
Specific effects of EEG based neurofeedback training on memory functions in post-stroke victims.
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DOI：
10.1186/s12984-015-0105-6
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发表时间：
2015-12-01
影响因子：
5.1
通讯作者：
Wood G
中科院分区：
文献类型：
--
作者：
Kober SE;Schweiger D;Witte M;Reichert JL;Grieshofer P;Neuper C;Wood G
使用基于脑电的神经反馈(NF)，大脑的活动直接受到调节，因此，认知功能的皮质底物本身也受到调节。在本研究中，我们调查了中风患者通过神经营养因子控制自己大脑活动的能力，并评估了不同神经营养因子方案对认知，特别是记忆恢复的具体影响。N = 17中风患者接受了长达10次的神经营养训练(N = 11，12-15赫兹)或上阿尔法(N = 6，例如10-12赫兹)核因子训练。N = 7卒中患者按常规治疗，作为对照。此外，N = 40名健康对照组也进行了神经营养训练。为了评估神经营养训练的效果，在神经营养训练前后进行了一组测试，以评估不同的认知功能。约70%的患者和对照组在神经营养能力方面取得了明显的进步，导致了言语短期和长期记忆的改善，而不受所使用的神经营养协议的影响。SMR患者组在视觉空间短期记忆性能方面表现出特定的改善，而High Alpha患者组则特别改善了他们的工作记忆性能。在中风患者中，神经营养因子训练的效果甚至比传统认知训练方法的效果更强。神经营养训练对记忆以外的其他认知功能没有影响。有记忆缺陷的中风后患者可以像健康对照组一样从神经营养训练中受益。所使用的神经营养训练方案(SMR、High Alpha)对记忆既有特定的影响，也有非特定的影响。因此，神经营养因子可能为改善卒中幸存者的记忆缺陷提供一种有效的认知康复工具。
Using EEG based neurofeedback (NF), the activity of the brain is modulated directly and, therefore, the cortical substrates of cognitive functions themselves. In the present study, we investigated the ability of stroke patients to control their own brain activity via NF and evaluated specific effects of different NF protocols on cognition, in particular recovery of memory. N = 17 stroke patients received up to ten sessions of either SMR (N = 11, 12–15 Hz) or Upper Alpha (N = 6, e.g. 10–12 Hz) NF training. N = 7 stroke patients received treatment as usual as control condition. Furthermore, N = 40 healthy controls performed NF training as well. To evaluate the NF training outcome, a test battery assessing different cognitive functions was performed before and after NF training. About 70 % of both patients and controls achieved distinct gains in NF performance leading to improvements in verbal short- and long-term memory, independent of the used NF protocol. The SMR patient group showed specific improvements in visuo-spatial short-term memory performance, whereas the Upper Alpha patient group specifically improved their working memory performance. NF training effects were even stronger than effects of traditional cognitive training methods in stroke patients. NF training showed no effects on other cognitive functions than memory. Post-stroke victims with memory deficits could benefit from NF training as much as healthy controls. The used NF training protocols (SMR, Upper Alpha) had specific as well as unspecific effects on memory. Hence, NF might offer an effective cognitive rehabilitation tool improving memory deficits of stroke survivors.