More Than 1 Year Continuous Operation of a Centrifugal Pump With a Magnetically Suspended Impeller
More Than 1 Year Continuous Operation of a Centrifugal Pump With a Magnetically Suspended Impeller
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磁悬浮叶轮离心泵连续运行1年以上
DOI：
10.1097/00002480-199709000-00041
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发表时间：
1997
期刊：
影响因子：
4.2
通讯作者：
T. Akutsu
中科院分区：
文献类型：
--
作者：
Chisato Nojiri;T. Kijima;Jun Maekawa;K. Horiuchi;T. Kido;T. Sugiyama;Takehisa Mori;N. Sugiura;T. Asada;H. Shimane;Kazunobu Nishimura;Toshihiko Ban;T. Akamatsu;T. Ozaki;H. Ito;Minoru Suzuki;T. Akutsu
作者一直在研制一种用于全人工心脏和长期心室支持的磁悬浮叶轮离心泵。MSCP由磁性轴承、叶轮和外壳以及驱动电机组成。叶轮由磁性轴承悬浮，因此叶轮在泵内提供接触自由旋转。本研究旨在评估慢性绵羊模型中MSCP的长期耐久性和非血栓形成性。采用肝素固定化技术（heaface）对泵和导管的血液接触面进行了彻底的修饰。在三只成年羊的左心室和降主动脉之间放置MSCP作为左心旁路。口服香豆素使凝血酶原时间维持在15-20秒。在整个实验过程中定期监测凝血和血液参数，包括血浆游离血红蛋白。在笼内的日常运动中，泵在1700 - 2000 rpm的转速下可以产生3-6 L/min （50-100 ml/kg）的平均流量。虽然动脉脉搏轮廓下降，但无生理性恶化。位置传感器监测的叶轮轴向偏移量<25 μ。血浆游离血红蛋白水平在整个实验过程中保持在<5 mg/dl。电机电流没有增加，说明叶轮周围没有大量血栓形成。其中一个实验由于电机霍尔传感器功能障碍，在第70天终止。回收的泵完全没有血栓形成。泵内及进出导管内未见血栓形成。在整个实验过程中，血液学、肾脏和肝脏参数保持在正常范围内。另外两只羊分别存活了395天和41天，没有出现重大并发症。这些研究表明，MSCP具有长期使用的巨大潜力。
The authors have been developing a centrifugal pump with a magnetically suspended impeller (MSCP) designed for total artificial heart and long-term ventricular support. The MSCP consists of a magnetic bearing, an impeller and housing, and a driving motor. The impeller is suspended by a magnetic bearing, therefore providing contact free rotation of the impeller inside the pump. This study was designed to evaluate long-term durability and nonthrombogenicity of the MSCP in a chronic sheep model. The blood contacting surfaces of the pump and conduits were completely modified by a heparin immobilization technique (Hepaface). The MSCP was placed paracorporeally as a left heart bypass between left ventricle and descending aorta in three adult sheep. Coumadin was given orally to maintain prothrombin time at 15–20 sec. The coagulation and hematologic parameters, including plasma free hemoglobin, were periodically monitored throughout the experiment. Under daily movement in the cage, the pump could produce average flow rates of 3–6 L/min (50–100 ml/kg) at 1,700–2,000 rpm. Although the arterial pulse contour decreased, there was no physiologic deterioration. The axial impeller excursion monitored by a position sensor was <25 μ. Plasma free hemoglobin level remained at <5 mg/dl throughout the experiment. There was no increase in the motor current, which indicates no massive thrombus formation around the impeller. One experiment was terminated at 70 days due to Hall sensor dysfunction of the motor. The retrieved pump was entirely free from thrombus formation. There was no detectable thrombus formation inside the pump or the inflow and outflow conduits. Hematologic, renal, and hepatic parameters remained within the normal range throughout the experiment. The other two sheep have survived for more than 395 and 41 days without major complication. These studies demonstrated that the MSCP has significant potential for long-term use.