Drinking behaviour in sea water and fresh water teleosts, the role of the renin-angiotensin system
Drinking behaviour in sea water and fresh water teleosts, the role of the renin-angiotensin system
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DOI：
10.1007/bf00004527
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发表时间：
1992-08
影响因子：
2.9
通讯作者：
M. Perrott;Christal E Grierson;Neil Hazon;R. Balment
中科院分区：
文献类型：
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作者：
M. Perrott;Christal E Grierson;Neil Hazon;R. Balment
在12种鱼的基础饮水率和反应，管理血管紧张素进行了检查。代表性广盐，狭盐海洋和淡水物种的内源性肾素-血管紧张素系统（RAS）活性的药理学操纵的反应也进行了调查。基础饮水率一直很低，在狭盐和广盐淡水鱼，所有物种的研究表明，增加吸胀响应管理血管紧张素。海洋鱼类喝大量的水，率有很大的不同物种之间，广盐性物种表现出较低的利率比狭盐性群体。在海蝎中观察到的极高饮水率与高血浆渗透压有关。除了海蝎，所有其他物种在海水中检测显示了进一步上升的饮用水响应外源性angiotensin.Although淡水狭盐性鲤鱼表现出dipsogenic反应血管紧张素，它显然是无法唤起这种反应时，鱼被驯化到微咸水。高饮用率的广盐性和狭盐性鱼类在海水中举行依赖于一个激活的内源性RAS，并降低抑制铝到所有转换由卡托普利。饮用水进一步刺激这些海洋物种刺激内源性RAS活性的管理局的消肿剂罂粟碱。这项研究赞同RAS在广盐性和窄盐性海洋硬骨鱼的自适应饮水控制中的作用。
Basal drinking rate and responses to administered angiotensin were examined in 12 species of fish. The responses of representative euryhaline, stenohaline marine and fresh water species to pharmacological manipulation of endogenous renin-angiotensin system (RAS) activity were also investigated.Basal drinking rates were consistently low in stenohaline and euryhaline fresh water fish, and all species examined showed an increased imbibition in response to administered angiotensin. Marine fish drank large volumes of water, rates varying considerably between species, with euryhaline species exhibiting lower rates than stenohaline groups. The extremely high drinking rates observed in the sea scorpion were associated with a high plasma osmolality. With the exception of the sea scorpion, all other species examined in sea water showed a further rise in drinking in response to exogenous angiotensin.Although the freshwater stenohaline carp showed a dipsogenic response to angiotensin, it was apparently unable to evoke this response when fish were acclimated to brackish water. The high drinking rates of both euryhaline and stenohaline fish held in sea water appeared dependent upon an activated endogenous RAS, and were lowered following inhibition of Al to All conversion by Captopril. Drinking was further stimulated in these marine species following stimulation of endogenous RAS activity by the administration of the hypotensive agent Papaverine. The study endorses a role for the RAS in the control of adaptive drinking in euryhaline and stenohaline marine teleosts.