Photocatalyzed Cascade Reactions of Cyclopropanols and α-Trifluoromethyl-Substituted Olefins for the Synthesis of Fused gem-Difluorooxetanes
Photocatalyzed Cascade Reactions of Cyclopropanols and α-Trifluoromethyl-Substituted Olefins for the Synthesis of Fused gem-Difluorooxetanes
复制标题
环丙醇和α-三氟甲基取代烯烃的光催化级联反应用于合成稠合宝石二氟氧杂环丁烷
DOI：
10.1002/anie.202212201
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Shen Xiao
中科院分区：
文献类型：
--
作者：
Zhang Yunxiao;Niu Yunhong;Guo Youyuan;Wang Jiaxin;Zhang Yizhi;Liu Shanshan;Shen Xiao
Fluorinated fused rings are challenging to construct from simple starting materials. Herein, we report the first photocatalyzed cascade reactions of readily available cyclopropanols andα‐trifluoromethyl‐substituted olefins for the synthesis of fusedgem‐difluorooxetanes. Two rings and three bonds were efficiently constructed in one reaction. The reaction showed broad substrate scope and the downstream transformations of the products demonstrated the synthetic potential of the reaction. The mechanistic study supported the presence of cascade photoredox catalysis and energy transfer catalysis/direct photo‐excitation processes.
