Prognostic significance of 18F-FDG uptake in primary osteosarcoma after but not before chemotherapy: a possible association with autocrine motility factor/phosphoglucose isomerase expression
Prognostic significance of 18F-FDG uptake in primary osteosarcoma after but not before chemotherapy: a possible association with autocrine motility factor/phosphoglucose isomerase expression
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DOI：
10.1007/s10585-008-9147-5
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发表时间：
2008-06-01
影响因子：
4
通讯作者：
Watanabe, Hideomi
中科院分区：
文献类型：
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作者：
Sato, Junko;Yanagawa, Takashi;Watanabe, Hideomi
对新辅助化疗的反应是骨肉瘤（OS）的重要预后因素。18-氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）是一种与肌肉骨骼肉瘤组织学分级相关的非侵入性成像方式。为了确定FDG PET在接受化疗的患者中的预后价值，对13例患者进行了FDG-PET评估，并随访了4年以上。分析化疗前（SUV 1）和化疗后（SUV 2）的FDG PET标准摄取值，并通过免疫组化检测手术切除肿瘤中转移相关糖酵解酶、自分泌运动因子（AMF）/磷酸葡萄糖异构酶（PGI）的表达。虽然OS伴转移性病灶患者的平均SUV 1与完全无病（CDF）组相似（分别为6.5 vs. 6.6，P = 0.975），但OS伴转移性病灶患者的平均SUV 2显著高于CDF组（分别为5.1 vs. 2.5，P = 0.0445）。有趣的是，使用抗AMF/PGI抗体的免疫组化分析显示，SUV 2与AMF/PGI染色滴度显著相关（P = 0.0303），而SUV 1与AMF/PGI染色滴度之间不存在相关性（P = 0.964）。本研究提示，化疗后FDGPET可提供术后切除区域外残留肿瘤转移潜能的相关信息，从而对患者预后有一定的预测价值。
Response to neoadjuvant chemotherapy is a significant prognostic factor for osteosarcoma (OS). 18-F-fluorodeoxy-D-glucose (FDG) positron emission tomography (PET) is a noninvasive imaging modality that correlates with histological grading in musculoskeletal sarcomas. To determine the prognostic value of FDG PET in patients receiving chemotherapy, 13 patients were evaluated by FDG-PET, and followed for more than 4 years. FDG PET standardized uptake values before (SUV1) and after (SUV2) chemotherapy were analyzed and correlated with the expression of metastasis-related glycolytic enzyme, autocrine motility factor (AMF)/phosphoglucose isomerase (PGI) by immunohistochemical examination in surgically excised tumors. Although mean SUV1 for OS patients with metastatic lesions were similar to those in the completely disease-free (CDF) group (6.5 vs. 6.6, respectively, P = 0.975), mean SUV2 for OS with metastatic lesions were significantly higher than those in the CDF group (5.1 vs. 2.5, respectively, P = 0.0445). Interestingly, immunohistochemical analysis using anti-AMF/PGI antibody revealed that SUV2 correlated significantly with the AMF/PGI staining titers (P = 0.0303), while no correlation between SUV1 and the AMF/PGI staining titers existed (P = 0.964). The present study suggests that FDG PET after chemotherapy may provide information for AMF/PGI-related metastatic potentiality of residual tumors located out side of the area surgically resected afterward, and then lead to a useful prediction of the patients' prognosis.