OPIATE RECEPTOR GRADIENTS IN MONKEY CEREBRAL-CORTEX - CORRESPONDENCE WITH SENSORY PROCESSING HIERARCHIES
OPIATE RECEPTOR GRADIENTS IN MONKEY CEREBRAL-CORTEX - CORRESPONDENCE WITH SENSORY PROCESSING HIERARCHIES
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DOI：
10.1126/science.6258227
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发表时间：
1981-01-01
期刊：
影响因子：
56.9
通讯作者：
PERT, A
中科院分区：
文献类型：
--
作者：
LEWIS, ME;MISHKIN, M;PERT, A
为了检查灵长类动物大脑皮层中内源性阿片剂的功能，测定μ-如阿片受体（其选择性结合3 H-标记的纳洛酮）和δ-评估了恒河猴整个大脑皮层的阿片样受体（其选择性结合3 H-标记的D-Ala 2、D-Leu 5-脑啡肽）。立体特异性[3 H]纳洛酮结合位点沿沿着分层组织的皮层系统以梯度增加，该皮层系统顺序处理逐渐更复杂性质的模态特异性感觉信息。特异性[3 H]脑啡肽结合位点相对均匀地分布在整个大脑皮层。猴子和人类的电生理学以及受体的分布暗示μ-类似的阿片受体可以在皮层水平的感觉刺激的有效过滤中起作用，即，情绪诱导的选择性注意力。
To examine the functions of endogenous opiates in the primate cerebral cortex, the distribution of .mu.-like opiate receptors (which selectively bind 3H-labeled naloxone) and .delta.-like opiate receptors (which selectively bind 3H-labeled D-Ala2, D-Leu5-enkephalin) throughout the cerebral cortex of the rhesus monkey was assessed. Stereospecific [3H]naloxone binding sites increased in a gradient along hierarchically organized cortical systems that sequentially process modality-specific sensory information of a progressively more complex nature. Specific [3H]enkephalin binding sites were relatively evenly distributed throughout the cerebral cortex. The electrophysiology of monkeys and humans and the distribution of receptors imply .mu.-like opiate receptors may play a role in the effective filtering of sensory stimuli at the cortical level, i.e., in emotion-induced selective attention.