New perspectives on vasoactive intestinal polypeptide as a widespread modulator of social behavior.
New perspectives on vasoactive intestinal polypeptide as a widespread modulator of social behavior.
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DOI：
10.1016/j.cobeha.2015.11.003
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发表时间：
2015-12-01
影响因子：
5
通讯作者：
Kingsbury MA
中科院分区：
文献类型：
--
作者：
Kingsbury MA
在生殖和社会功能方面，血管活性肠肽(VIP)被认为是脊椎动物催乳素分泌的主要调节因子，因此是父母照料的重要贡献者。然而，VIP及其同源VPAC受体分布于大脑的社会行为网络中，提示VIP回路可能在各种行为中发挥重要作用。除了视交叉上核和下丘脑结节中的VIP神经元群(分别调节昼夜节律和催乳素的分泌)外，直到最近，我们对VIP回路的功能特性知之甚少。本文着重介绍了VIP信号在鸟类社会行为中的新作用，如联结、群居、配对结合和攻击行为，并讨论了VIP作为生物节律调节器的最新进展，包括潜在的排卵时间、光周期反应和季节性迁徙。
In terms of reproductive and social functions, vasoactive intestinal polypeptide (VIP) is best known as a major regulator of prolactin secretion in vertebrates and hence, as an essential contributor to parental care. However, VIP and its cognate VPAC receptors are distributed throughout the social behavior network in the brain, suggesting that VIP circuits may play important roles in a variety of behaviors. With the exception of VIP neuronal populations in the suprachiasmatic nucleus and tuberal hypothalamus (which regulate circadian rhythms and prolactin secretion, respectively), we have known very little about the functional properties of VIP circuits until recently. The present review highlights new roles for VIP signaling in avian social behaviors such as affiliation, gregariousness, pair bonding and aggression, and discusses recent advances in VIP’s role as a regulator of biological rhythms, including the potential timing of ovulation, photoperiodic response and seasonal migration.