Functional Similarity of Medial Superior Parietal Areas for Shift-Selective Attention Signals in Humans and Monkeys
Functional Similarity of Medial Superior Parietal Areas for Shift-Selective Attention Signals in Humans and Monkeys
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DOI：
10.1093/cercor/bhx114
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发表时间：
2018-06-01
期刊：
影响因子：
3.7
通讯作者：
Vanduffel, Wim
中科院分区：
文献类型：
--
作者：
Caspari, Natalie;Arsenault, John T.;Vanduffel, Wim
我们不断地在视觉环境中的物品之间转移注意力。这些注意力转移通常是基于任务相关性（自上而下）或突然的、意想不到的刺激的显著性（自下而上），并且通常伴随着目标导向的行动。可以说，任何能够隐蔽地转移注意力的物种都将依赖于类似的、进化上保守的神经基质来处理这种转移信号。为了解决这种可能性，我们在人类和猴子身上进行了比较fMRI实验，结合了传统和新颖的数据驱动分析方法。具体来说，我们研究了猴子和人类大脑区域之间的对应关系，在隐蔽注意力转移过程中激活。当“转移”事件与“停留”事件进行比较时，内侧（上级）顶叶（mSPL）和顶叶下叶在不同物种中表现出相似的转移敏感性，而猴子的额叶激活更强。为了以数据驱动的方式识别与人类移位选择性SPL相对应的猴子区域，我们使用了一种新的物种间β相关策略，其中任务相关的β值在两个物种的体素或感兴趣区域之间相关。猴内侧顶叶区V6/V6 A与移位选择性人mSPL最一致相关。我们的研究结果表明，这两个物种招募相应的，进化保守的区域内内侧上级顶叶转移空间注意力。
We continually shift our attention between items in the visual environment. These attention shifts are usually based on task relevance (top-down) or the saliency of a sudden, unexpected stimulus (bottom-up), and are typically followed by goal-directed actions. It could be argued that any species that can covertly shift its focus of attention will rely on similar, evolutionarily conserved neural substrates for processing such shift-signals. To address this possibility, we performed comparative fMRI experiments in humans and monkeys, combining traditional, and novel, data-driven analytical approaches. Specifically, we examined correspondences between monkey and human brain areas activated during covert attention shifts. When "shift" events were compared with "stay" events, the medial (superior) parietal lobe (mSPL) and inferior parietal lobes showed similar shift sensitivities across species, whereas frontal activations were stronger in monkeys. To identify, in a data-driven manner, monkey regions that corresponded with human shift-selective SPL, we used a novel interspecies beta-correlation strategy whereby task-related beta-values were correlated across voxels or regions-of-interest in the 2 species. Monkey medial parietal areas V6/V6A most consistently correlated with shift-selective human mSPL. Our results indicate that both species recruit corresponding, evolutionarily conserved regions within the medial superior parietal lobe for shifting spatial attention.