Tumor-induced osteomalacia.
Tumor-induced osteomalacia.
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DOI：
10.1001/jama.294.10.1260
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发表时间：
2005-09
期刊：
影响因子：
--
通讯作者：
S. Jan de Beur
中科院分区：
文献类型：
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作者：
S. Jan de Beur
肿瘤诱导的骨软化症（TIO）是一种罕见的肾磷酸盐消耗的副肿瘤形式，可导致严重的低磷酸盐血症、维生素D代谢缺陷和骨软化症。这种衰弱性疾病的临床表现说明了一个55岁的妇女进行性疲劳，虚弱，肌肉和骨骼疼痛与骨折。经过长期的临床过程和广泛的实验室评估，肿瘤引起的骨软化症被确定为她的临床表现的基础。在这篇文章中，这种综合征的独特的临床特点，TIO的诊断进展，以及这种疾病的病理生理学的新见解进行了讨论。
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic form of renal phosphate wasting that results in severe hypophosphatemia, a defect in vitamin D metabolism, and osteomalacia. This debilitating disorder is illustrated by the clinical presentation of a 55-year-old woman with progressive fatigue, weakness, and muscle and bone pain with fractures. After a protracted clinical course and extensive laboratory evaluation, tumor-induced osteomalacia was identified as the basis of her clinical presentation. In this article, the distinctive clinical characteristics of this syndrome, the advances in diagnosis of TIO, and new insights into the pathophysiology of this disorder are discussed.