ESTIMATION OF STROKE VOLUME IN DOG BY A PULSE CONTOUR METHOD
ESTIMATION OF STROKE VOLUME IN DOG BY A PULSE CONTOUR METHOD
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DOI：
10.1161/01.res.26.5.611
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发表时间：
1970-01-01
影响因子：
20.1
通讯作者：
MCDONALD, DA
中科院分区：
文献类型：
--
作者：
KOUCHOUKOS, NT;SHEPPARD, LC;MCDONALD, DA
在12只麻醉的开胸犬身上测试了一种从单通道中央主动脉压记录的收缩期面积估计卒中容量（SV）的方法。公式为SV = K·Psa·（1 + Ts/Td），其中Psa为舒张末压以上曲线收缩期下的面积，Ts和Td分别为收缩期和舒张期的持续时间，K是电磁流量计测量每只狗的初始SV后得到的任意常数，此后在该狗中使用不变。在12只狗中，在正常和改变循环条件下，采用12种不同的干预措施，比较了541种压力轮廓法和电磁流量计法同时测定的SV。SV总范围为2.4 ~ 28.1 ml，心率35 ~ 207/min，平均动脉压24 ~ 166 mm Hg，总相关系数(r)为0.928，回归线y = 1.04x + 0.21 ml (SE)，估计±17.4%。除3种拟交感神经药物外，其他干预措施的r值在0.93 ~ 0.99之间。这些观察结果与先前报道的脉冲轮廓方法相比较有利。指出了公式的风帆起源，并对“水锤”方程进行了修正，给出了新的推导。
A method for estimating the stroke volume (SV) from the systolic area of a single-channel record of the central aortic pressure has been tested in 12 anesthetized open-chest dogs. The formula used was SV = K·Psa·(1 + Ts/Td), where Psa is the area under the systolic part of the curve above end-diastolic pressure, Ts and Td are the durations of systole and diastole, respectively, and K is an arbitrary constant derived from measurement of an initial SV by electromagnetic flowmeter in each dog and used thereafter without change, in that dog. In the 12 dogs, 541 simultaneous determinations of SV by the pressure contour and electromagnetic flowmeter methods were compared under normal and altered circulatory conditions employing 12 different interventions. The total range of SV was 2.4 to 28.1 ml, of heart rate 35 to 207/min, and of mean arterial pressure 24 to 166 mm Hg. The overall correlation coefficient (r) was 0.928 with a regression line y = 1.04x + 0.21 ml (SE) of estimate, ±17.4%. Except for three sympathomimetic drugs, the r values for all other interventions ranged from 0.93 to 0.99. These observations compare favorably with those of previously reported pulse contour methods. The windkessel origin of the formula is noted, and a new derivation from a modification of the "water-hammer" equation is given.