Abnormal Sense of Agency in Patients with Schizophrenia: Evidence from Bimanual Coupling Paradigm.
Abnormal Sense of Agency in Patients with Schizophrenia: Evidence from Bimanual Coupling Paradigm.
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DOI：
10.3389/fnbeh.2016.00043
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发表时间：
2016
影响因子：
3
通讯作者：
Rocca P
中科院分区：
文献类型：
--
作者：
Garbarini F;Mastropasqua A;Sigaudo M;Rabuffetti M;Piedimonte A;Pia L;Rocca P
要理解人类的行动意识，一个富有成效的方法是研究那些改变了某些方面的病理学。先前的证据表明，精神分裂症患者倾向于将别人的行为归因于自己的行为，因为这是内部而不是外部产生的。在这里，我们问精神分裂症患者是否有一个“过度”的代理感，同时观察别人的动作。我们利用了圆-线任务，已知显示双手干扰。20名精神分裂症患者和20名年龄匹配的健康对照者被给予：（a）双手版本的任务：用一只手画线，另一只手画圈;（B）修改版本：一边画线，一边观察检查者画圈。在双手版本中，患者和对照组显示出相当的干扰效应。在观察版本中，精神分裂症患者，与控制相比，表现出显着更大的干扰效果的考官的手绘圆圈对自己的手绘线。这种效果显着相关的积极症状（幻觉和妄想）的强度和代理感的改变，在任务期间报告。这些发现表明，精神分裂症患者所表现出的能动感的改变，可以对运动系统产生客观的影响。
A fruitful approach to the understanding the human awareness of action is the study of those pathologies in which some aspects of it are altered. Previous evidences showed that patients with schizophrenia tend to attribute someone else’ actions to their own, as internally, rather than externally, generated. Here, we asked whether schizophrenics have an “excessive” sense of agency, while observing others’ movements. We took advantage from the circles-lines task, known to show bimanual interferences. Twenty schizophrenics and 20 age-matched healthy controls were administered: (a) the bimanual version of the task: drawing lines with one hand and circles with the other; and (b) a modified version: drawing lines while observing the examiner drawing circles. In the bimanual version, patients and controls showed a comparable interference effect. In the observation version, schizophrenics, compared to controls, showed a significantly greater interference effect of the examiners’ hand drawing circles on the own hand drawing lines. This effect was significantly correlated to the strength of the positive symptoms (hallucinations and delusions) and to the alteration of the sense of agency, reported during the task. These findings suggest that an altered sense of agency, as shown by schizophrenics, can induce objective consequences on the motor system.