Intratympanic corticosteroids for sudden idiopathic sensorineural hearing loss
Intratympanic corticosteroids for sudden idiopathic sensorineural hearing loss
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DOI：
10.1097/01.mao.0000185052.07513.5a
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发表时间：
2005-09-01
影响因子：
2.1
通讯作者：
Parnes, LS
中科院分区：
文献类型：
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作者：
Banerjee, A;Parnes, LS
目的：确定鼓室内类固醇滴注对于治疗突发特发性感音神经性听力损失是否有效。方法：对 1996 年至 2002 年期间在三级护理大学耳科诊所接受鼓室内类固醇治疗（甲泼尼龙和/或地塞米松）的所有患者进行回顾性图表审查。确定了 33 名患者，其中 26 名符合特发性听力损失的纳入标准。比较治疗前和治疗后的纯音听力图和言语辨别分数。结果：总体而言，纯音阈值提高了 27.2 +/- 5.7dB，言语辨别分数提高了 25.4 +/- 6.2%。发病后 10 天内接受治疗的患者比 10 天后接受治疗的患者具有统计学上显着更好的结果。未报告不良反应或并发症。结论：鼓室内滴注类固醇是治疗突发特发性感音神经性听力损失的一种安全且可能有效的方法。
Objective: To determine whether instillation of intratympanic steroids is effective in the treatment of sudden idiopathic sensorineural hearing loss.Methods: A retrospective chart review of all patients who underwent intratympanic steroid treatment (methylprednisolone and/or dexamethasone) between 1996 and 2002 at a tertiary care university otology clinic. Thirty-three patients were identified, of which 26 met inclusion criteria for having an idiopathic hearing loss. Pretreatment and posttreatment pure-tone audiograms and speech discrimination scores were compared.Results: Overall, there was a 27.2 +/- 5.7dB improvement in the pure-tone thresholds and a 25.4 +/- 6.2% improvement in speech discrimination scores. Those treated within 10 days of onset had a statistically significant better outcome than those treated after 10 days. No adverse reactions or complications were reported.Conclusion: Instillation of intratympanic steroids represents a safe and potentially effective treatment of sudden idiopathic sensorineural hearing loss.