MicroRNA regulation of allergic inflammation and asthma.
MicroRNA regulation of allergic inflammation and asthma.
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DOI：
10.1016/j.coi.2015.07.006
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发表时间：
2015-10
影响因子：
7
通讯作者：
Ansel KM
中科院分区：
文献类型：
--
作者：
Pua HH;Ansel KM
HighlightsmiRNAs调节变态反应性炎症和过敏反应。miRNAs通过靶基因网络协调作用。miRNAs影响2型免疫细胞的多种细胞功能。miRNAs为变态反应提供新的生物标志物和治疗策略。变态反应疾病普遍存在，临床上存在异质性，是不适当或过度的2型免疫反应的病理后果。在这篇综述中，我们探索了microRNAs(MiRNAs)在调节变态反应性炎症中的作用。我们讨论了miRNAs如何通过靶基因调控基因表达网络，影响对2型免疫反应至关重要的免疫细胞功能的多个方面，包括细胞生存、增殖、分化和效应功能。人类和小鼠的研究表明，miRNAs是过敏免疫反应的重要调节因子。最后，对细胞外miRNAs的研究为非侵入性生物标志物和过敏和哮喘的治疗策略提供了希望。
HighlightsmiRNAs regulate allergic inflammation and allergic responses.miRNAs act coordinately through target gene networks.miRNAs impact diverse cellular functions in type 2 immune cells.miRNAs provide novel biomarkers and therapeutic strategies in allergy.Allergic diseases are prevalent and clinically heterogeneous, and are the pathologic consequence of inappropriate or exaggerated type 2 immune responses. In this review, we explore the role of microRNAs (miRNAs) in regulating allergic inflammation. We discuss how miRNAs, acting through target genes to modulate gene expression networks, impact multiple facets of immune cell function critical for type 2 immune responses including cell survival, proliferation, differentiation, and effector functions. Human and mouse studies indicate that miRNAs are significant regulators of allergic immune responses. Finally, investigations of extracellular miRNAs offer promise for noninvasive biomarkers and therapeutic strategies for allergy and asthma.