Importance of tyrosine phosphorylation for transmembrane signaling in plants.
Importance of tyrosine phosphorylation for transmembrane signaling in plants.
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酪氨酸磷酸化在植物跨膜信号传递中的重要性。
DOI：
10.1042/bcj20210202
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发表时间：
2021-07-30
期刊：
影响因子：
--
通讯作者：
Zipfel C
中科院分区：
文献类型：
--
作者：
Mühlenbeck H;Bender KW;Zipfel C
可逆的蛋白质磷酸化是一种广泛的翻译后修饰，对生命的所有领域的信号传导至关重要。酪氨酸（Tyr）磷酸化对于植物受体激酶（RK）介导的信号传导（特别是在植物免疫期间）是重要的。然而，Tyr磷酸化如何调节RK功能在很大程度上是未知的。值得注意的是，蛋白质酪氨酸磷酸酶和SH 2结构域的蛋白质家族，这是在choanozoans调节磷酸酪氨酸（pTyr）网络的核心，没有发生在植物中。在这里，我们总结了目前对植物RK Tyr磷酸化的了解，重点关注几种植物RK中保守的pTyr位点（“VIa-Tyr”）的关键作用。此外，我们讨论的可能性，后生动物样pTyr信号模块在植物中的非典型成分的基础上收敛的生化功能。
Reversible protein phosphorylation is a widespread post-translational modification fundamental for signaling across all domains of life. Tyrosine (Tyr) phosphorylation has recently emerged as being important for plant receptor kinase (RK)-mediated signaling, particularly during plant immunity. How Tyr phosphorylation regulates RK function is however largely unknown. Notably, the expansion of protein Tyr phosphatase and SH2 domain-containing protein families, which are the core of regulatory phospho-Tyr (pTyr) networks in choanozoans, did not occur in plants. Here, we summarize the current understanding of plant RK Tyr phosphorylation focusing on the critical role of a pTyr site (‘VIa-Tyr’) conserved in several plant RKs. Furthermore, we discuss the possibility of metazoan-like pTyr signaling modules in plants based on atypical components with convergent biochemical functions.
影响因子：
4.4
作者：
Christofk, Heather R.;Wu, Ning;Cantley, Lewis C.;Asara, John M.
通讯作者：
Asara, John M.