Relationship Between Polyunsaturated Fatty Acids and Psychopathology in the NEURAPRO Clinical Trial
Relationship Between Polyunsaturated Fatty Acids and Psychopathology in the NEURAPRO Clinical Trial
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DOI：
10.3389/fpsyt.2019.00393
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发表时间：
2019-06-06
影响因子：
4.7
通讯作者：
Amminger, G. Paul
中科院分区：
文献类型：
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作者：
Berger, Maximus;Nelson, Barnaby;Amminger, G. Paul
背景资料：膜多不饱和脂肪酸（PUFA）如ω-3（n-3）脂肪酸的缺陷被认为有助于精神障碍的病理生理过程。新出现的证据表明，PUFA水平与临床症状有关，但研究之间存在显着的异质性。在这里，我们调查了膜PUFA与临床症状和功能在一个大样本的个人在超高风险（UHR）为psychiatrice.Methods：共285名参与者的NEURAPRO临床试验进行了调查红细胞PUFA水平，包括n-3指数，n-6/n-3 PUFA比例，二十二碳六烯酸（DHA），和二十碳五烯酸（EPA）。一般精神病理学严重程度[简明精神病评定量表（BPRS）]、精神病性症状（BPRS精神病子量表）、阴性症状[阴性症状评估量表（SANS）]、躁狂症状[杨氏躁狂量表（YMRS）]、抑郁症状[蒙哥马利阿斯伯格抑郁量表（MADRS）]和功能[社会和职业功能量表（SOFAS），同时评估全球功能社会（GF-S）和角色（GF-R）量表。偏相关考虑到性别，年龄和吸烟的影响被用来检查PUFAs和症状severity.Results之间的关系：n-3指数与一般精神病理学，精神病性症状，抑郁症状，躁狂症状的严重程度呈负相关。n-6/n-3 PUFA比值与精神病性和抑郁症状的严重程度呈正相关。n-3 PUFA DHA与一般精神病理学、阳性、躁狂和抑郁症状的严重程度呈负相关。EPA与躁狂症状呈负相关。神经酸是一种n-9单不饱和脂肪酸，与一般精神病理学、阳性和阴性症状、抑郁症状和躁狂症状呈正相关。长链饱和脂肪酸tetracosanoic acid与一般精神病理学，阳性，躁狂，抑郁symptoms.Conclusions：部分符合以前的研究，精神病症状，抑郁症状，躁狂症状与几个类的脂肪酸在本研究中。这些发现支持膜脂肪酸与精神病症状发作的相关性，并表明脂肪酸应进一步评估为精神病组UHR的生物标志物。
Background: Deficiencies in membrane polyunsaturated fatty acids (PUFA) such as omega-3 (n-3) fatty acids are thought to contribute to the pathophysiological processes underlying psychotic disorders. Emerging evidence suggests that the levels of PUFA are related to clinical symptoms but significant heterogeneity exists between studies. Here, we investigated associations of membrane PUFA with clinical symptoms and functioning in a large sample of individuals at ultra-high risk (UHR) for psychosis.Methods: A total of 285 participants of the NEURAPRO clinical trial were investigated for erythrocyte PUFA levels, including the n-3 index, n-6/n-3 PUFA ratio, docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA). Severity of general psychopathology [Brief Psychiatric Rating Scale (BPRS)], psychotic symptoms (BPRS psychosis subscale), negative symptoms [Scale for the Assessment of Negative Symptoms (SANS)], manic symptoms [Young Mania Rating Scale (YMRS)], depressive symptoms [Montgomery Asberg Depression Rating Scale (MADRS)], and functioning [Social and Occupational Functioning Scale (SOFAS), Global Functioning Social (GF-S) and Role (GF-R) scales] were assessed concurrently. Partial correlation taking into account the effects of gender, age, and smoking was used to examine the relationship between PUFAs and symptoms severity.Results: The n-3 index negatively correlated with the severity of general psychopathology, psychotic symptoms, depressive symptoms, and manic symptoms. The n-6/n-3 PUFA ratio positively correlated with severity of psychotic and depressive symptoms. The n-3 PUFA DHA negatively correlated with the severity of general psychopathology, positive, manic, and depressive symptoms. EPA negatively correlated with manic symptoms. Nervonic acid, an n-9 monounsaturated fatty acid, positively correlated with general psychopathology, positive and negative symptoms, depressive symptoms, and manic symptoms. The long-chain saturated fatty acid tetracosanoic acid positively correlated with general psychopathology, positive, manic, and depressive symptoms.Conclusions: Partially consistent with a previous study, psychotic symptoms, depressive symptoms, and symptoms of mania were associated with several classes of FAs in the present study. These findings support the relevance of membrane fatty acids for the onset of psychotic symptoms and indicate that FAs should be further evaluated as biomarkers in the UHR for psychosis group.