Effect of sodium intake on the excretion of urinary natriuretic factor in essential hypertensives.
Effect of sodium intake on the excretion of urinary natriuretic factor in essential hypertensives.
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钠摄入量对原发性高血压患者尿利钠因子排泄的影响。
DOI：
10.1507/endocrj1954.32.405
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
R. Takeda
中科院分区：
文献类型：
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作者：
T. Morise;I. Miyamori;S. Hifumi;S. Okamoto;M. Ikeda;Y. Takeda;H. Koshida;S. Yasuhara;R. Takeda
研究了一种用地高辛样物质测定尿液中利尿钠因子的简化方法。通过反相筒柱提取但不进行凝胶过滤后，使用抗地高辛抗体通过放射免疫分析来估计尿液中的地高辛样物质。放射免疫测定 (RIA) 发现的值与 Na-K-ATP 酶活性的抑制效果显着相关，Na-K-ATP 酶活性是通过 Hamlyn 等人所述的生化测定法测量的。使用这种 RIA 方法，研究了原发性高血压患者盐摄入量对尿液中利尿钠因子的影响。与低钠饮食（氯化钠 3 克/天）相比，高钠饮食（氯化钠 20 克/天，三天）的利尿钠因子增加了约 1.5 倍（p 小于 0.05）。当患者接受ad治疗时，钠尿因子与尿Na排泄呈正相关（P小于0.050）。库。钠饮食。从这些结果来看，尿液中利尿钠因子的分泌可能部分受到盐摄入量的调节。
A simplified method for the determination of natriuretic factor in the urine as measured by digoxin-like substance was studied. Digoxin-like substance in the urine was estimated by RIA using anti-digoxin antibody after being extracted by reversed phase cartridge column but without gel filtration. The values found by radioimmunoassay (RIA) yielded a significant correlation with those of the inhibitory effect of Na-K-ATPase activity which was measured by biochemical assay as described by Hamlyn et al. Using this RIA method, the effect of salt intake on natriuretic factor in urine was studied in patients with essential hypertension. The natriuretic factor on a high sodium diet (NaCl 20 g/day for three days) increased approximately 1.5 times, as compared to those on a low sodium diet (NaCl 3 g/day) (p less than 0.05). The Natriuretic factor showed a positive correlation with urinary Na excretion (P less than 0.050) when the patients were placed on ad. lib. sodium diet. From these results, it is suggested that secretion of natriuretic factor in the urine might be regulated in part by salt intake.