1H,1′H-[3,3′]biindolyl from the terrestrial fungus Gliocladium catenulatum
1H,1′H-[3,3′]biindolyl from the terrestrial fungus Gliocladium catenulatum
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DOI：
10.1038/ja.2010.103
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发表时间：
2010-11-01
影响因子：
3.3
通讯作者：
Cabrera, Gabriela M.
中科院分区：
文献类型：
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作者：
Bertinetti, Brenda V.;Alejandra Rodriguez, M.;Cabrera, Gabriela M.
粘帚霉属是一个以产生生物活性次级代谢产物而闻名的属。萜烯、1，2-含硫二酮哌嗪3和聚酮化合物4只是这些化合物的不同结构和生物活性的几个例子。一些粘帚霉菌株也在商业上用作防治害虫的生物防治剂。5美洲蜜蜂幼虫病是由幼虫类芽孢杆菌（Paenibacillus larvae）引起的蜜蜂幼虫和蛹的一种疾病，给蜜蜂的生产造成了重大的经济损失。由于缺乏有效的治疗方法，养蜂业生产者使用商业抗生素，产生已知的后果，如获得对这些药物的耐药性机制，以及对蜂箱、蜂蜜和人类消费的其他产品造成污染。由于上述原因，我们开始寻找针对由真菌培养物产生的P.幼虫的特异性抗生素，以提高这种生产活性。
Gliocladium is a genus known for its production of bioactive secondary metabolites. Terpenes, 1, 2 sulfur-containing diketopiperazines 3 and polyketides 4 are just a few examples of the diverse structural and biological activity of these compounds. Some Gliocladium strains are also employed commercially as biocontrol agents in the field against pests. 5American foulbrood is a disease of the larvae and pupae of honeybees caused by the bacterium Paenibacillus larvae, which produces important economical losses. Owing to the lack of effective treatments, apiculture producers employ commercial antibiotics generating known consequences such as acquisition of resistant mechanisms to those drugs and introduction of contamination to the beehives and honey and other products of human consumption. For the above reasons, we began the search for specific antibiotics against P. larvae produced by fungal cultures in order to improve this productive activity.