Near-Infrared Light-Responsive Composite Microneedles for On-Demand Transdermal Drug Delivery
Near-Infrared Light-Responsive Composite Microneedles for On-Demand Transdermal Drug Delivery
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DOI：
10.1021/acs.biomac.5b00185
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发表时间：
2015-05-01
影响因子：
6.2
通讯作者：
Chen, Dong-Hwang
中科院分区：
文献类型：
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作者：
Chen, Mei-Chin;Ling, Ming-Hung;Chen, Dong-Hwang
这项研究提出了近红外（NIR）光响应聚合物纳米结构复合微针，用于按需经皮给药。将二氧化硅涂层的六硼化镧（LaB6@SiO2）纳米结构纳入聚己内酯微针中，充当：近红外吸收剂。当微针受到近红外光照射时，LaB6@SiO2 纳米结构介导的光热传导导致微针在 50 摄氏度下熔化。这增加了聚合物链的流动性，从而使药物能够从基质中释放。评估了微针的药物释放：四个激光开/关循环。每个循环中，对样品进行辐照直至温度达到50℃，持续3分钟（激光开启）；然后关闭激光 30 分钟（激光关闭）。结果表明，聚合物中的光诱导相变触发了药物从熔化的微针中释放。在多次近红外光照射循环后观察到逐步的药物释放行为。关闭状态下未发现明显的药物泄漏。这种近红外光触发装置具有出色的再现性、低断态泄漏和无创触发能力，因此代表了透皮给药技术的“进步”。
This study presents near-infrared (NIR) light-responsive polymer-nanostitcture composite microneedles used for on-demand trans dermal chug delivery. Silica-coated lanthanum hexaboride (LaB6@SiO2) nanostructures were incorporated into polycaprolactone microneedles, serving as: an NIR absorber. When the microneedles were irradiated with NIR light, light-to-heat transduction mediated by the LaB6@SiO2 nanostructures caused the microneedle melting at 50 degrees C. This increased the mobility of the polymer chains,, enabling drug release from the matrix. Drug release from the microneedles was evaluated: for four laser on/off cycles. In each cycle, the samples were irradiated until the temperature reached 50 degrees C for 3 min (laser on); the laser was then turned off for 30 min (laser off). The results showed that light-induced phase transition in the polymer triggered drug release from the Melted microneedles. A stepwise drug-release behavior was observed after Multiple cycles of NIR light exposure. No notable drug leakage was found in the off state. This,NIR-light-triggerable device exhibits excellent reproducibility, low off-state leakage, and noninvasive triggerability and, thus, represents an 'advance' in transdermal delivery technology.