Thalamic Circuit Mechanisms Link Sensory Processing in Sleep and Attention.
Thalamic Circuit Mechanisms Link Sensory Processing in Sleep and Attention.
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DOI：
10.3389/fncir.2015.00083
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发表时间：
2015
影响因子：
3.5
通讯作者：
Halassa MM
中科院分区：
文献类型：
--
作者：
Chen Z;Wimmer RD;Wilson MA;Halassa MM
睡眠完整性和注意力表现之间的相关性通常被解释为睡眠不佳导致注意力受损。在这里，我们为这种相关性提供了另一种解释：共同的丘脑回路调节睡眠和注意力的感觉处理，它们的中断可能导致相关的功能障碍。利用小鼠多电极记录，我们发现丘脑网状核（TRN）神经元的速率和节律性预测其在睡眠中的功能组织，并暗示它们参与跨状态的感觉处理。令人惊讶的是，与睡眠中的纺锤波相关的TRN神经元也与注意力期间的α振荡相关。因此，我们提出，共同的丘脑回路原则调节感觉处理的状态不变的方式，在某些疾病，针对这些电路可能是一个更可行的治疗策略，而不是考虑单独的状态。
The correlation between sleep integrity and attentional performance is normally interpreted as poor sleep causing impaired attention. Here, we provide an alternative explanation for this correlation: common thalamic circuits regulate sensory processing across sleep and attention, and their disruption may lead to correlated dysfunction. Using multi-electrode recordings in mice, we find that rate and rhythmicity of thalamic reticular nucleus (TRN) neurons are predictive of their functional organization in sleep and suggestive of their participation in sensory processing across states. Surprisingly, TRN neurons associated with spindles in sleep are also associated with alpha oscillations during attention. As such, we propose that common thalamic circuit principles regulate sensory processing in a state-invariant manner and that in certain disorders, targeting these circuits may be a more viable therapeutic strategy than considering individual states in isolation.