A meta-analytic review of the association between two common SNPs in miRNAs and lung cancer susceptibility.
A meta-analytic review of the association between two common SNPs in miRNAs and lung cancer susceptibility.
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miRNA 中两个常见 SNP 与肺癌易感性关联的荟萃分析综述
DOI：
10.2147/ott.s156505
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发表时间：
2018
影响因子：
4
通讯作者：
Lu X
中科院分区：
文献类型：
--
作者：
Xiao S;Sun S;Long W;Kuang S;Liu Y;Huang H;Zhou J;Zhou Y;Lu X
MicroRNAs （miRNAs）参与许多生物过程，包括肿瘤抑制。多项研究表明miRNA-196a2 rs11614913和miRNA-146a rs2910164多态性与癌症风险之间存在关联。然而，报告数据的含义是有争议的和不确定的。材料与方法检索PubMed、EMBASE、中国知网、万方数据库，检索时间为2007年1月1日至2017年4月30日。根据指定的纳入和排除标准对研究进行评估，数据由两名研究者手动从相关研究中提取。计算合并优势比（ORs）和95%置信区间（CIs），探讨mirna中两个单核苷酸多态性（snp）与肺癌易感性之间的关系。结果纳入9篇符合条件的文章，包括miRNA-196a2 rs11614913的3101例癌症病例和3234例对照，miRNA-146a rs2910164的3483例病例和3578例对照。在评估miRNA-196a2 rs11614913的研究中，发现miRNA-196a2 rs11614913与肺癌风险显著相关。总体而言，合并分析显示miRNA-196a2 rs11614913与降低癌症风险相关（CC vs TT: OR = 1.25, 95% CI: 1.09-1.44; CT vs TT: OR = 1.26, 95% CI: 1.03-1.53）。对于miRNA-146a rs2910164，仅发现CC基因型与高肺癌风险相关（OR = 1.30, 95% CI: 1.13-1.49）。基于种族、对照组来源和国家的亚组分析表明，miRNA-146a rs2910164与癌症风险之间存在很强的相关性。结论miRNA-196a2 rs11614913和miRNA-146a rs2910164与肺癌发病风险显著相关。mirna中这两个常见的snp可能是肺癌的潜在生物标志物。
Background MicroRNAs (miRNAs) are involved in many biological processes, including tumor suppression. Multiple studies have shown an association between the miRNA-196a2 rs11614913 and miRNA-146a rs2910164 polymorphisms and cancer risk. However, the implications of the reported data are debatable and inconclusive. Materials and methods Relevant articles were retrieved from the PubMed, EMBASE, China National Knowledge Infrastructure, and WanFang databases from January 1, 2007, to April 30, 2017. Studies were assessed based on designated inclusion and exclusion criteria, and data were manually extracted from relevant studies by two investigators. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to explore the association between two single-nucleotide polymorphisms (SNPs) in miRNAs and lung cancer susceptibility. Results Nine eligible articles were included, consisting of 3,101 cancer cases and 3,234 controls for miRNA-196a2 rs11614913, and 3,483 cases and 3,578 controls for miRNA-146a rs2910164. For studies evaluating miRNA-196a2 rs11614913, significant associations with lung cancer risk were discovered. Overall, the pooled analysis showed that miRNA-196a2 rs11614913 was associated with a decreased cancer risk (CC vs TT: OR = 1.25, 95% CI: 1.09–1.44; CT vs TT: OR = 1.26, 95% CI: 1.03–1.53). For miRNA-146a rs2910164, only the CC genotype was found to be associated with high lung cancer risk (OR = 1.30, 95% CI: 1.13–1.49). Subgroup analyses based on ethnicity, source of control group, and country indicated that there were strong associations between miRNA-146a rs2910164 and cancer risk. Conclusion The results indicated that lung cancer risk was significantly associated with miRNA-196a2 rs11614913 and miRNA-146a rs2910164. These two common SNPs in miRNAs may be potential biomarkers of lung cancer.