Essential fatty acid metabolism and requirements for LBW infants.
Essential fatty acid metabolism and requirements for LBW infants.
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低出生体重婴儿的必需脂肪酸代谢和需求。
DOI：
10.1111/j.1651-2227.1994.tb13403.x
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Hoffman,DR
中科院分区：
文献类型：
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作者：
Uauy-Dagach,R;Mena,P;Hoffman,DR
人类不能合成亚油酸（LA）（18：2 ω-6）和α-亚麻酸（LNA）（18：3 ω-3）。大多数配方奶粉提供充足的LA，但婴儿有ω-3缺乏的风险，除非他们喂母乳。30周出生的新生儿接受人乳或随机分配到三种配方奶粉中：配方A，基于玉米油，类似于旧的商业配方奶粉;配方B，基于LNA提供的豆油;或配方C，类似于B的产品，添加海洋油以提供二十二碳六烯酸（22：6 ω-3）。血浆和红细胞的脂肪酸具有显著的饮食诱导差异。视杆细胞检测显示ω-3缺乏的婴儿阈值更高，敏感性降低。在57周随访时，视力也显示人乳和C组婴儿的脑皮质功能改善。这些结果表明，ω-3脂肪酸是视觉功能最佳发育所必需的。
Humans are unable to synthesize linoleic acid (LA) (18: 2ω‐6) and α‐linolenic acid (LNA) (18: 3ω‐3). Most formulas provide ample LA, yet infants are at risk for ω‐3 deficiency unless they are fed human milk. Neonates born at 30 weeks received human milk or were randomized to three formulas: formula A, based on corn oil, similar to old commercial formula; formula B, based on soy oil supplied LNA; or formula C, a product similar to B with added marine oil to provide docosahexaenoic acid (22:6 ω‐3). The fatty acids of plasma and red blood cells had marked diet‐induced differences. The rod photoreceptor tests demonstrated higher threshold and decreased sensitivity in the ω‐3‐deficient infants. Visual acuity also showed improved function of the brain cortex in the human milk and group C infants at follow‐up at 57 weeks. These results suggest that ω‐3 fatty acids are needed for optimal development of visual function.