The elongation, termination, and recycling phases of translation in eukaryotes.

The elongation, termination, and recycling phases of translation in eukaryotes.
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DOI:
10.1101/cshperspect.a013706
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发表时间:
2012-07-01
影响因子:
7.2
通讯作者:
Green R
Green R
中科院分区:
生物学1区
文献类型:
--
作者:
Dever TE;Green R

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这项工作总结了我们目前的理解真核蛋白质合成的延伸和终止/回收阶段。我们在这里集中在该领域的最新进展。除了翻译延伸的概述,我们讨论了真核翻译延伸的独特方面,包括eEF 1回收,eEF 2修饰,eEF 3和eIF 5A功能。同样,我们强调了真核释放因子eRF 1和eRF 3在翻译终止中的功能,以及ABCE 1/Rli 1、Dom 34:Hbs 1复合物和Ligatin(eIF 2D)在核糖体回收中的功能。最后,我们提出了一些关键问题,翻译延长,终止和回收,仍然有待回答。
This work summarizes our current understanding of the elongation and termination/recycling phases of eukaryotic protein synthesis. We focus here on recent advances in the field. In addition to an overview of translation elongation, we discuss unique aspects of eukaryotic translation elongation including eEF1 recycling, eEF2 modification, and eEF3 and eIF5A function. Likewise, we highlight the function of the eukaryotic release factors eRF1 and eRF3 in translation termination, and the functions of ABCE1/Rli1, the Dom34:Hbs1 complex, and Ligatin (eIF2D) in ribosome recycling. Finally, we present some of the key questions in translation elongation, termination, and recycling that remain to be answered.
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