Duloxetine compared with placebo for treating women with symptoms of overactive bladder
Duloxetine compared with placebo for treating women with symptoms of overactive bladder
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DOI：
10.1111/j.1464-410x.2007.06980.x
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发表时间：
2007-08-01
影响因子：
4.5
通讯作者：
Bump, Richard C.
中科院分区：
文献类型：
--
作者：
Steers, William D.;Herschorn, Sender;Bump, Richard C.
目的 评估度洛西汀（一种 5-羟色胺-去甲肾上腺素再摄取抑制剂）对有膀胱过度活动症 (OAB) 症状的女性的作用，因为它已被证明可以在动物模型中增加膀胱容量。 患者和方法 总共招募了 306 名女性（年龄 21-84 岁），并随机分配到安慰剂组 (153 名) 或度洛西汀组（80 毫克/天，持续 4 周增加至 120 毫克/天） 8 周；153）。 OAB 的症状被定义为令人烦恼的尿急和/或急迫性尿失禁 (UI) ≥ 3 个月。参与者还需要平均白天排尿间隔 (VI)
Objective To evaluate duloxetine (a serotonin-noradrenaline reuptake inhibitor) in women with symptoms of overactive bladder (OAB), as it has been shown to increase the bladder capacity in an animal model.Patients and methods In all, 306 women (aged 21-84 years) were recruited and randomly assigned to placebo (153) or duloxetine (80-mg/day for 4 weeks increased to 120-mg/day for 8 weeks; 153). Symptoms of OAB were defined as bothersome urinary urgency and/or urge urinary incontinence (UI) for >= 3 months. Participants were also required to have a mean daytime voiding interval (VI) of