Cannabis and cancer chemotherapy: a comparison of oral delta-9-THC and prochlorperazine.
Cannabis and cancer chemotherapy: a comparison of oral delta-9-THC and prochlorperazine.
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大麻和癌症化疗：口服 delta-9-THC 和丙氯拉嗪的比较。
DOI：
10.1002/1097-0142(19820815)50:4
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发表时间：
1982
期刊：
影响因子：
6.2
通讯作者：
Jamison,K
中科院分区：
文献类型：
--
作者：
Ungerleider,JT;Andrysiak,T;Fairbanks,L;Goodnight,J;Sarna,G;Jamison,K
delta -9-四氢大麻酚（THC）和prochlorperazine （Compazine）在减少癌症化疗相关的恶心和呕吐方面被发现在广泛的化疗方案和肿瘤类型中同样有效。这两种药物在化疗前一小时口服，然后每四小时口服一次，共服用四次。吡嗪以固定剂量10mg给药；四氢大麻酚按体表面积（BSA）给药：BSA小于1.4 m2= 7.5 mg；BSA 1.4-1.8 m2= 10 mg；BSA大于1.8 m2= 12.5 mg。采用双盲交叉设计对214名受试者（其中75%先前接受过compine，结果不同）进行评估。评估的其他参数包括研究药物对食欲、食物摄入、情绪、活动、放松、相互作用和注意力的影响。四氢大麻酚有显著的药物效应：集中能力下降（P < 0.01），社交能力下降（P < 0.05），活动能力下降（P < 0.05）。两种药物在食物摄入水平或食欲方面没有显著差异。所有年龄段的患者服用这两种药物效果都一样好。过去使用大麻和过去使用Compazine与研究药物疗效无关。正确识别四氢大麻酚周期的患者在四氢大麻酚治疗方面优于不能正确识别服用哪种止吐药的患者（P < 0.05）。与四氢大麻酚相关的药物相关效应更多，但这并没有降低患者对药物的偏好，而且与恶心减轻有关（P < 0.05）。
Delta-9-tetrahydrocannabinol (THC) and prochlorperazine (Compazine) were found to be equally efficacious in reducing nausea and vomiting associated with cancer chemotherapy across a wide range of chemotherapeutic regimens and tumor types. Both drugs were administered orally one hour before chemotherapy, then every four hours for a total of four doses. Compazine was administered in a fixed dose of 10 mg; THC was administered by body surface area (BSA): BSA less than 1.4 m2= 7.5 mg; BSA 1.4-1.8 m2= 10-mg; and BSA greater than 1.8 m2= 12.5 mg. Two hundred and fourteen subjects (75% of whom had previously received Compazine with varying results) were evaluated employing a double-blind, crossover design. Additional parameters evaluated were study drug effects on appetite, food intake, mood, activity, relaxation, interaction, and concentration. There were significant drug effects with THC: less ability to concentrate (P less than 0.01), less social interaction (P less than 0.05), and less activity (P less than 0.05). There were no significant differences between the two drugs in the level of food intake or appetite. Patients of all ages did equally well on both drugs. Neither past marijuana use nor past Compazine use were related to study the drug efficacy. Those patients who correctly identified their THC cycle did better on THC versus those who could not correctly identify which antiemetic they had received (P less than 0.05). There were more drug-related effects associated with THC, but these did not reduce the patients' preference for the drug, and were associated with nausea reduction (P less than 0.05).