The human immunodeficiency virus and the cardiometabolic syndrome in the developing world: an African perspective.
The human immunodeficiency virus and the cardiometabolic syndrome in the developing world: an African perspective.
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DOI：
10.1111/j.1559-4572.2008.07584.x
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发表时间：
2008-01-01
期刊：
影响因子：
--
通讯作者：
Cade, W Todd
中科院分区：
文献类型：
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作者：
Mutimura, Eugene;Crowther, Nigel J;Cade, W Todd
高效抗逆转录病毒疗法（HAART）的出现已将人类免疫缺陷病毒（HIV）/艾滋病转变为一种可控制的慢性疾病。然而，临床护理需要解决与HIV感染和HAART相关的代谢、人体测量和心血管变化。在发展中国家进行的研究表明，艾滋病毒相关的心脏代谢综合征（CMS）的发病率正在增加，特别是在城市环境中。预测表明，由于生活方式的改变，未来20年非洲的糖尿病患病率将出现最大幅度的增加。这一点，再加上获得高效抗逆转录病毒疗法的机会增加，可能会成倍增加CMS在艾滋病毒感染流行的发展中国家的流行率。需要在发展中国家，特别是撒哈拉以南非洲实施适当的评估和干预方案，以减少与艾滋病毒有关的CMS。这应该包括常规的心血管风险评估，用更“代谢友好”的HAART管理HIV感染，鼓励改变生活方式，特别是戒烟，体重管理，定期锻炼和坚持健康饮食。
The advent of highly active antiretroviral therapy (HAART) has transformed human immunodeficiency virus (HIV)/AIDS into a manageable chronic disorder. Clinical care, however, needs to address the metabolic, anthropometric, and cardiovascular changes associated with HIV infection and HAART. Studies in developing countries suggest an increasing incidence of HIV-associated cardiometabolic syndrome (CMS), especially in urban settings. Predictions indicate that the greatest increase in the prevalence of diabetes will occur in Africa over the next 2 decades due to lifestyle changes. This, coupled with increased access to HAART, may exponentially increase the prevalence of CMS in developing countries, where HIV infection is prevalent. Appropriate evaluation and intervention programs need to be implemented in the developing world, especially sub-Saharan Africa, to curtail HIV-related CMS. This should include routine cardiovascular risk assessments, management of HIV infection with more "metabolically friendly" HAART, and encouragement of lifestyle modifications, particularly smoking cessation, weight management, regular exercise, and adherence to a healthy diet.