Relationship between serum adiponectin and bone mineral density in male patients with obstructive sleep apnea syndrome
Relationship between serum adiponectin and bone mineral density in male patients with obstructive sleep apnea syndrome
复制标题
男性阻塞性睡眠呼吸暂停综合征患者血清脂联素与骨密度的关系
DOI：
10.1007/s11325-017-1492-7
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发表时间：
2017-05-01
影响因子：
2.5
通讯作者：
Zhao, Jian-Ming
中科院分区：
文献类型：
--
作者：
Chen, Dong-Dong;Huang, Jie-Feng;Zhao, Jian-Ming
目的阻塞性睡眠呼吸暂停综合征（OSAS）与骨密度（BMD）有关。然而，根本的机制还远不清楚。本研究的目的是探讨OSAS、骨转换标志物与骨密度之间的关系，并评价脂联素对OSAS患者骨密度的影响。方法71例男性OSAS患者和13例男性对照者参加了本研究。测定所有受试者的血清脂联素、钙、磷、25-羟维生素D3、I型胶原β-异构化形式C末端肽、骨钙素和1型前胶原N-前肽，并采用双能X线骨密度仪（DEXA）评估腰椎（L1-L4）、股骨颈、和髋关节total.ResultsNo统计学显着差异，研究组之间的人口统计学数据和骨转换标志物。血清脂联素水平随着OSAS的加重而显著降低。与非OSAS患者相比，OSAS患者髋部总BMD和t评分显著增高（p= 0.027和p = 0.028）。血清脂联素水平与髋部骨密度呈显著负相关。调整混杂因素后，脂联素和氧去饱和指数（ODI）显著预测了髋部总BMD（β= − 0.232，p = 0.005和β= 0.226，p = 0.037）。结论在男性受试者中，阻塞性睡眠呼吸暂停综合征的存在与髋部较高的骨密度相关。这些结果表明，血清脂联素可能是一个潜在的中介BMD的OSAS。
PurposeObstructive sleep apnea syndrome (OSAS) is reported to have an association with bone mineral density (BMD). However, the underlying mechanism is far from clear. The aim of this study was to investigate the relationship between OSAS, bone turnover markers, and BMD and to evaluate the effect of adiponectin on BMD in patients with OSAS.MethodsSeventy-one male patients with OSAS and 13 male control subjects were enrolled in this study. Serum adiponectin, calcium, phosphorus, 25-hydroxyvitamin-D3, β-isomerized form C-terminal telopeptide of type I collagen, osteocalcin, and procollagen type 1N-propeptide were measured in all subjects, and BMD was evaluated by dual-energy X-ray absorptiometry (DEXA) in the lumbar spine (L1–L4), the femoral neck, and the hip total.ResultsNo statistically significant differences were found between the studied groups in terms of demographic data and bone turnover markers. Serum adiponectin significantly decreased with the aggravation of OSAS. Compared with subjects without OSAS, those with OSAS had a higher hip total BMD andtscores (p= 0.027 andp= 0.028). The significant negative association was found between serum adiponectin levels and hip total BMD. After adjusting for confounders, adiponectin as well as oxygen desaturation index (ODI) significantly predicted the hip total BMD (β= −0.232,p= 0.005 andβ= 0.226,p= 0.037).ConclusionsIn male subjects, the presence of obstructive sleep apnea syndrome is associated with higher bone mineral density of the hip. These findings suggest that serum adiponectin may be an underlying mediator for BMD in OSAS.