Effect of metoclopramide on mivacurium‐induced neuromuscular block
Effect of metoclopramide on mivacurium‐induced neuromuscular block
复制标题
甲氧氯普胺对米库溴铵神经肌肉阻滞的影响
DOI：
10.1034/j.1399-6576.2002.460217.x
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发表时间：
2002
影响因子：
2.1
通讯作者：
Philippe Duvaldestin
中科院分区：
文献类型：
--
作者：
C. Motamed;K. Kirov;X. Combes;Gilles Dhonneur;Philippe Duvaldestin
为探讨甲氧氯普胺对美维库铵作用时间的影响，将45例患者随机分为3组。M10组（n = 15）和M20组（n = 15）分别静脉注射甲氧氯普胺10和20 mg， S组（n = 15）在芬太尼、硫喷妥钠和米库铵诱导前2min给予生理盐水。 分别于麻醉诱导前及注射胃复安和生理盐水后2min测定血浆胆碱酯酶活性（pCHE）。 神经肌肉阻滞监测的力传感器使用四个神经刺激的列车。用异氟烷和N2O维持麻醉。M10组和M20组恢复90%抽搐高度的时间分别为44 ± 15和57 ± 10 min，明显长于S组（32 ± 9 min，P <0.05）。 在M20组中观察到pCHE轻微但显著降低。由于米伐库铵作用持续时间延长的风险，在注射米伐库铵前给予甲氧氯普胺时，应始终监测神经肌肉阻滞。
In order to investigate the effect of metoclopramide on the duration of action of mivacurium, 45 patients were randomized into three groups. Group M10 (n = 15) and M20 (n = 15) received 10 and 20 mg of metoclopramide i.v., respectively, and group S (n = 15) received saline 2 min before induction of anesthesia with fentanyl, thiopental and mivacurium. Plasma cholinesterase activity (pCHE) was measured before induction of anesthesia and 2 min after injection of metoclopramide and saline. Neuromuscular block was monitored by a force transducer using train of four nerve stimulation. Anesthesia was maintained with isoflurane and N2O. Time to recovery of a twitch height of 90% was significantly prolonged in group M10 and M20 (44 ± 15 and 57 ± 10 min) as compared to group S, 32 ± 9 min, P < 0.05). A slight but significant decrease in pCHE was observed in group M20. Because of the risk of prolonged duration of action of mivacurium, neuromuscular blockade should always be monitored whenever metoclopramide is given before injection of mivacurium.