Effect of p21WAF1/CIP1 expression on tumor progression in bladder cancer
Effect of p21WAF1/CIP1 expression on tumor progression in bladder cancer
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DOI：
10.1093/jnci/90.14.1072
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发表时间：
1998-07-15
期刊：
影响因子：
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通讯作者：
Cote, RJ
中科院分区：
文献类型：
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作者：
Stein, JP;Ginsberg, DA;Cote, RJ
背景：p53蛋白表达的改变是膀胱癌进展的重要预测因子。p53对细胞周期调控的作用部分是通过细胞周期蛋白依赖性激酶抑制剂p21（WAF 1/CIP 1）（p21）的表达介导的。因此，p21表达可能有助于肿瘤进展。我们试图确定膀胱癌中p21表达与疾病进展之间的关系。方法：收集242例膀胱癌患者行膀胱灌注化疗的肿瘤标本。中位随访时间为8.5年（范围：0.1-11.8年）。核p21状态通过免疫组化确定，然后分析与肿瘤复发概率、总生存率和肿瘤p53状态的关系。结果：242例患者中，156例（64%）肿瘤细胞核p21表达阳性，p21阳性患者的肿瘤复发率降低（P
Background: Altered expression of p53 protein is an important predictor of progression in bladder cancer. The action of p53 on cell cycle regulation is mediated, in part, through expression of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) (p21), Loss of p21. expression may, therefore, contribute to tumor progression, We sought to determine the relationship between p21 expression in bladder cancer and disease progression. Methods: Tumor specimens were obtained from 242 patients who underwent cystectomy for bladder cancer. Median follow-up was 8.5 years (range, 0.1-11.8 years). Nuclear p21 status was determined by immunohistochemistry and was then analyzed in relationship to the probability of tumor recurrence, overall survival, and tumor p53 status. Reported P values are two-sided, Results: Nuclear p21 expression was detected in the tumors of 156 (64%) of the 242 patients, Patients with p21-positive tumors had a decreased probability of tumor recurrence (P