A new neurobehavioral model of autism in mice: Pre- and postnatal exposure to sodium valproate
A new neurobehavioral model of autism in mice: Pre- and postnatal exposure to sodium valproate
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DOI：
10.1007/s10803-006-0117-y
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发表时间：
2006-08-01
影响因子：
3.9
通讯作者：
Halladay, Alycia K.
中科院分区：
文献类型：
--
作者：
Wagner, George C.;Reuhl, Kenneth R.;Halladay, Alycia K.
自闭症症状，包括语言发育，社会互动和运动技能的障碍，很难在啮齿动物中建模。由于宫内暴露于丙戊酸钠（VPA）的儿童表现出与自闭症相似的行为和神经解剖学异常，因此在出生前或出生后给药后，在小鼠中检查了这种抗癫痫药物的神经发育影响。在一系列神经发育程序中评价暴露的幼仔，这些程序旨在评估VPA诱导的发育迟缓（其中行为未能按时成熟）、退化（其中行为按时成熟但随后恶化）或侵入（其中正常行为被刻板或自我伤害行为所掩盖）。由此产生的观察结果被解释在这种新的策略来模拟自闭症的背景下。
Autism symptoms, including impairments in language development, social interactions, and motor skills, have been difficult to model in rodents. Since children exposed in utero to sodium valproate (VPA) demonstrate behavioral and neuroanatomical abnormalities similar to those seen in autism, the neurodevelopmental effects of this antiepileptic agent were examined in mice following its pre- or postnatal administration. Exposed pups were evaluated in a battery of neurodevelopmental procedures designed to assess VPA-induced retardation (wherein a behavior fails to mature on schedule), regression (wherein a behavior does mature on time but then deteriorates), or intrusions (wherein normal behaviors are overshadowed by stereotypic or self-injurious behaviors). The resulting observations were interpreted in the context of this new strategy to model autism.