Top-down regulation of default mode activity in spatial visual attention.
Top-down regulation of default mode activity in spatial visual attention.
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空间视觉注意中默认模式活动的自上而下调节
DOI：
10.1523/jneurosci.4939-12.2013
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发表时间：
2013-04-10
期刊：
影响因子：
--
通讯作者：
Ding M
中科院分区：
文献类型：
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作者：
Wen X;Liu Y;Yao L;Ding M
背侧前扣带回和双侧前扣带回构成了一个任务控制网络（TCN），其主要功能是启动和维持任务水平的认知定势，并对感觉运动加工进行自上而下的调节。默认模式网络（DMN），包括一组解剖学上不同的皮层区域，调解内省和自我参照的过程。静息态数据显示TCN和DMN相互作用。它们相互作用的功能性后果仍然难以捉摸。记录人类受试者执行视觉空间注意任务的fMRI数据，并将格兰杰因果影响与行为表现和血氧水平依赖（BOLD）活动相关联，我们报告了三个主要发现。首先，TCN对DMN的因果影响，即，TCN → DMN与行为绩效呈正相关。第二，从DMN到TCN的因果影响，即，DMN → TCN与行为绩效呈负相关。第三，较强的DMN → TCN与TCN中BOLD活性升高较少相关，而TCN → DMN与DMN BOLD活性之间的关系是不系统的。这些结果表明，在视觉空间注意，自上而下的信号从TCN到DMN调节DMN的活动，以提高行为性能，而从DMN到TCN的信号，可能作为内部噪声，干扰任务控制，导致行为性能下降。
Dorsal anterior cingulate and bilateral anterior insula form a task control network (TCN) whose primary function includes initiating and maintaining task-level cognitive set and exerting top-down regulation of sensorimotor processing. The default mode network (DMN), comprising an anatomically distinct set of cortical areas, mediates introspection and self-referential processes. Resting-state data show that TCN and DMN interact. The functional ramifications of their interaction remain elusive. Recording fMRI data from human subjects performing a visual spatial attention task and correlating Granger causal influences with behavioral performance and blood oxygen level-dependent (BOLD) activity we report three main findings. First, causal influences from TCN to DMN, i.e., TCN → DMN, are positively correlated with behavioral performance. Second, causal influences from DMN to TCN, i.e., DMN → TCN, are negatively correlated with behavioral performance. Third, stronger DMN → TCN are associated with less elevated BOLD activity in TCN, whereas the relationship between TCN → DMN and DMN BOLD activity is unsystematic. These results suggest that, during visual spatial attention, top-down signals from TCN to DMN regulate the activity in DMN to enhance behavioral performance, whereas signals from DMN to TCN, acting possibly as internal noise, interfere with task control, leading to degraded behavioral performance.