Co-expression of Y box-binding protein-1 and P-glycoprotein as a prognostic marker for survival in epithelial ovarian cancer
Co-expression of Y box-binding protein-1 and P-glycoprotein as a prognostic marker for survival in epithelial ovarian cancer
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DOI：
10.1016/j.ygyno.2004.01.040
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发表时间：
2004-05-01
影响因子：
4.7
通讯作者：
Kohno, K
中科院分区：
文献类型：
--
作者：
Huang, X;Ushijima, K;Kohno, K
目标。本研究旨在观察Y盒结合蛋白1（YB-1）和P-糖蛋白（P-gp）在原发性卵巢肿瘤中的表达，并确定它们是否作为上皮性卵巢癌生存的生物标志物。方法。对1997年至2000年久留米大学医院收治的59例患者进行免疫组化检查YB-1和P-gp的表达。样品是取自手术标本的石蜡包埋的原发性卵巢癌组织。结果。在检查的 59 个原发性卵巢肿瘤中，YB-1 和 P-gp 分别为 32 个（54.2%）和 18 个（30.5%）阳性。在 20.3% (12/59) 的病例中观察到这两种蛋白的共表达。显示这种共表达的患者的 3 年生存率比那些没有共表达的患者差（40.0% vs. 73. 1 %，P < 0.0447）。根据多变量分析，这种共表达与不良预后显着相关（P = 0.0007）。结论。 YB-1 和 P-gp 的共表达成为卵巢癌不良预后的有前景的相关生物标志物。 (C) 2004 Elsevier Inc. 保留所有权利。
Objectives. This study aimed to observe the expressions of Y box-binding protein-1 (YB-1) and P-glycoprotein (P-gp) in primary ovarian tumor and to determine whether they act as biomarkers for survival in epithelial ovarian cancer.Methods. The expressions of YB-1 and P-gp were examined immunohistochemically in 59 patients who were treated from 1997 to 2000 at Kurume University Hospital. Samples were paraffin-embedded primary ovarian cancer tissue taken from the surgical specimens.Results. Of the 59 primary ovarian tumors examined, 32 (54.2%) and 18 (30.5%) were positive for YB-1 and P-gp, respectively. Coexpression of these two proteins was observed in 20.3% (12/59) cases. Patients showing this co-expression had a worse 3-year survival than those without co-expression (40.0% vs. 73. 1 %, P 0.0447). This co-expression significantly correlated with poor prognosis according to multivariate analysis (P = 0.0007).Conclusion. Co-expression of YB-1 and P-gp emerged as a promising relevant biomarker for unfavorable prognosis in ovarian cancer. (C) 2004 Elsevier Inc. All rights reserved.